Abstract
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase, which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase domain in complex with imatinib.
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Acknowledgements
We would like to thank Drs. Sonja Alexandra Dames and Martin Allan for their help during the initial phase of the project. This work was supported by SNF grant 31-109712 (S.G.) and Novartis Pharma AG.
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Below is the link to the electronic supplementary material. Table containing the list of specifically labeled samples used for the assignment.
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Vajpai, N., Strauss, A., Fendrich, G. et al. Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib. Biomol NMR Assign 2, 41–42 (2008). https://doi.org/10.1007/s12104-008-9079-7
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DOI: https://doi.org/10.1007/s12104-008-9079-7