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A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)

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Abstract

The low-density lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. Mesoderm development (MESD) protein is a 195-residue protein that functions as a specialized molecular chaperone to promote the proper folding of the six-bladed β-propeller/EGF modules of the LDL receptor family members. Here we report a complete NMR spectral assignment of the most conserved region of MESD protein, MESD(12-155).

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Acknowledgements

This work was supported by NIH RO1 grants (HL074365 and HL076620 to J.W.). Jianglei Chen is supported by a predoctoral fellowship from the American Heart Association (AHA 0515582Z to J.C.).

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI, 48201, USA

    Jianglei Chen & Jianjun Wang

  2. Departments of Pediatrics, and of Cell Biology and Physiology, Washington University School of Medicine, CB 8208, St. Louis, MO, 63110, USA

    Guojun Bu

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  1. Jianglei Chen
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  2. Guojun Bu
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  3. Jianjun Wang
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Correspondence to Jianjun Wang.

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Chen, J., Bu, G. & Wang, J. A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155). Biomol NMR Assign 1, 3–5 (2007). https://doi.org/10.1007/s12104-007-9003-6

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  • DOI: https://doi.org/10.1007/s12104-007-9003-6

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