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Bone Mineral Content and Density in Healthy Term Indian Infants at the Age of 1 and 2 Years Assessed by Dual-Energy X-Ray Absorptiometry

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Abstract

There is a paucity of data on the bone mineral status of infants, with no data from India. This study was undertaken to assess the bone mineral content (BMC) of the healthy term Indian infants at 1 and 2 y of age, and the influence of factors such as birth weight, gender, current size, and vitamin D levels on BMC. Anthropometry, serum 25-hydroxyvitamin-D levels, and dual-energy X-ray absorptiometry (DXA) for the lumbar spine and whole-body BMC were performed at the ages of 1 and 2 y.

Mean whole-body BMC was 214.1 ± 40.8 g at 1 y (n = 131) and 327.6 ± 87.4 g at 2 y (n = 73); lumbar spine BMC was 6.9 ± 1.8 g at 1 y and 10.2 ± 3.8 g at 2 y. The chief determinants of BMC were the weight and length/height of the infant, with no effect of vitamin D levels. The BMC of Indian infants at 1 y was similar to that reported previously for Caucasian infants.

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Acknowledgements

The authors thank Ms. Sapna Khatak, Staff Nurse, and Mr. Anuj Kumar, Project Technician, for their help with subject enrollment and study measurements.

Funding

Department of Biotechnology, Government of India (Grant No. BT/PR3884/Med/97/ 03/2011).

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Authors and Affiliations

  1. Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Vandana Jain & Brijesh Kumar

  2. Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India

    Manisha Jana

Authors
  1. Vandana Jain
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  2. Brijesh Kumar
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  3. Manisha Jana
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Contributions

VJ conceived and supervised the study, analyzed the data, and wrote the manuscript; BK enrolled the subjects, conducted their anthropometric and biochemical measurements, and analyzed the data; MJ supervised the DXA measurements and helped in the interpretation of the BMC data. All authors have contributed to the manuscript, and approved the final version. VJ will act as the guarantor for this paper.

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Correspondence to Vandana Jain.

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Ethics Approval

AIIMS Ethics Committee; No. IEC/NP-127/2012 and RP-21/2012, dated April 27, 2012.

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Jain, V., Kumar, B. & Jana, M. Bone Mineral Content and Density in Healthy Term Indian Infants at the Age of 1 and 2 Years Assessed by Dual-Energy X-Ray Absorptiometry. Indian J Pediatr 90, 190–192 (2023). https://doi.org/10.1007/s12098-022-04412-9

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  • DOI: https://doi.org/10.1007/s12098-022-04412-9

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