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Comparison of Asthma Control among Children 5–18 Years of Age by Asthma Control Test Questionnaire of Global Initiative for Asthma 2017 (GINA-2017) Against Spirometry

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Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To compare asthma control by Asthma Control Test (ACT)/Childhood Asthma Control Test (cACT) Questionnaire of Global Initiative for Asthma 2017 (GINA-2017) against spirometry in children, 5–18 y of age, with asthma.

Methods

A prospective observational study was conducted between July 2017 and March 2019 in pulmonology OPD of a tertiary care center. Children with asthma aged 5–18 y, falling under the inclusion criteria had spirometry and cACT/ACT questionnaire before starting inhaled corticosteroids. After 12 wk, symptom control was reassessed by ACT/cACT and spirometry. Chi-square/Fischer exact test and paired t-test/Mann–Whitney U test used for qualitative and quantitative data, respectively.

Results

ACT/cACT pretreatment score was 12.76 (2.521), and at follow-up the score was 23.94 (1.941) (p < 0.001). Control by GINA increased from 2.04% to 91.84% at follow-up (p < 0.001). Significant improvement in forced expiratory volume in first second (FEV1), forced expiratory volume/forced vital capacity (FEV1/FVC), forced expiratory flow between 25 and 75% of FVC (FEF25−75) and peak expiratory flow rate (PEFR) between pretreatment and follow-up seen were −71.86%, 106.84%, 101.82%, and 97.51% vs. 82.2%, 109.55%, 110.38%, and 107.00%, respectively. Positive correlation between ACT/cACT and FEV1 (r = 0.26, p ≤ 0.05), PEFR (r = 0.30, p ≤ 0.05).

Conclusions

There is a good correlation of symptom control between ACT/cACT and spirometry with significant positive correlation for FEV1, PEFR.

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Authors and Affiliations

  1. Department of Pediatrics, Mehta Multispeciality Hospitals India Pvt. Ltd, Chennai, Tamil Nadu, India

    Jahnavi M

  2. Sai Nilayam, New No. 4, Old No. 26, 7th Main Road R.A. Puram, Chennai, Tamil Nadu, 600028, India

    Jahnavi M

  3. Department of Pediatrics—Operations & Quality, Mehta Multispeciality Hospitals India Pvt. Ltd, Chennai, Tamil Nadu, India

    Gowrishankar N.C

  4. Department of Research and Academics, Mehta Multispeciality Hospitals India Pvt. Ltd, Chennai, Tamil Nadu, India

    Nedunchelian K

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  1. Jahnavi M
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  2. Gowrishankar N.C
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  3. Nedunchelian K
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Contributions

GNC conceived the idea and design of the study; JM collected the data and prepared the draft; GNC and NK critically reviewed the draft. GNC will act as the guarantor for this paper.

Corresponding author

Correspondence to Jahnavi M.

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The study was approved by the Institutional Ethics Committee and performed in line with the principles of the Declaration of Helsinki (IRB-MCH/22/2017).

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Informed consent was obtained from the parents of the children.

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M, J., N.C, G. & K, N. Comparison of Asthma Control among Children 5–18 Years of Age by Asthma Control Test Questionnaire of Global Initiative for Asthma 2017 (GINA-2017) Against Spirometry. Indian J Pediatr 90, 770–775 (2023). https://doi.org/10.1007/s12098-022-04162-8

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  • DOI: https://doi.org/10.1007/s12098-022-04162-8

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