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Prevalence and Determinants of Occurrence of Dyslipidemia in Subjects with Type 1 Diabetes Mellitus

Abstract

Objective

To describe the prevalence and determinants of occurrence of dyslipidemia in children and adolescents with type 1 diabetes mellitus (T1DM).

Methods

A cross-sectional study was conducted in the diabetic clinic of a tertiary care referral hospital over two years. Subjects with T1DM aged 2–18 y had assessment of Lipid profile after 12 h of fasting. Glycemic control was assessed by glycosylated hemoglobin (HbA1C). Modifiable and nonmodifiable determining factors were assessed during clinic visit as per standard criteria. Body mass index (BMI) more than 23rd adult equivalent and 27th adult equivalent were considered as overweight and obesity, respectively. Lipid parameters were considered as abnormal if: Low density lipoprotein (LDL) > 100 mg/dL, high density lipoprotein (HDL) < 40 mg/dL, triglycerides > 100 mg/dL (< 10 y) and > 130 mg/dL (> 10 y).

Results

A total of 171 subjects (mean age: 11.8 ± 3.5 y, M:F = 75:96) were recruited during the study period. The mean fasting LDL level, HDL level, and triglyceride level observed in the study sample were 106.6 ± 26.9 mg/dL (62% abnormal), 52.6 ± 14.3 mg/dL (9.4% abnormal), and 85.3 ± 39.4 mg/dL (10.5% abnormal), respectively; 115 (67.3%) of the subjects had at least one abnormality in the serum lipid profile. On multivariate analysis, HbA1C was the most significant factor in determining the occurrence of dyslipidemia (p < 0.05). HbA1C was 9.9 ± 1.6 in subjects with abnormal LDL versus 9.1 ± 1.5 in those with normal LDL (p < 0.05).

Conclusion

Prevalence of dyslipidemia in the study children and adolescents with T1DM was 67.3%. HbA1C remains the most important modifiable determinant of the occurrence of dyslipidemia.

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Data Availability

On request.

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Acknowledgements

The authors would like to thank Prof Nedunchelian K. for reading and reviewing this manuscript. They also thank all the children and their families for participating in this study.

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Authors and Affiliations

Authors

Contributions

MS was involved in data collection and tabulation; HKP, TS, BP, and SW were involved in the clinical management of cases and study conceptualization; BP and TS were involved in data analysis; SW, HKP, BP, TS contributed to the manuscript; All authors have read the final manuscript and approve the final version of the manuscript. HKP will act as the guarantor for this paper.

Corresponding author

Correspondence to Hemchand Krishna Prasad.

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Ethics Approval

The study was approved by Mehta Mutispeciality Hospitals IEC, Chennai. Approval number/IRB number: IRB-MCH/011/2019.

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None.

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Selvaraj, M., Prasad, H.K., White, S. et al. Prevalence and Determinants of Occurrence of Dyslipidemia in Subjects with Type 1 Diabetes Mellitus. Indian J Pediatr (2022). https://doi.org/10.1007/s12098-022-04130-2

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Keywords

  • Dyslipidemia
  • Type 1 diabetes mellitus
  • Obesity
  • Glycosylated hemoglobin