Abstract
This study evaluated 32 children (mean age: 8.5 y) with autism spectrum disorder (ASD) and 23 healthy controls (similar age, sex, and Tanner stage) for hyperandrogenism. These children underwent sexual maturity rating (Tanner staging), ASD severity assessment (Childhood Autism Rating Scale), and quantitative estimation for plasma testosterone, dehydroepiandrosterone sulfate (DHEAS), and androstenedione. There was no significant difference in androgen levels in the two groups. Elevated (> 95 centiles) testosterone, DHEAS, and androstenedione levels were seen in 12.3%, 6.2%, and 9% children with ASD, and 7/9 of these children (78%) with hyperandrogenism had severe ASD. However, there was no significant correlation between ASD severity and androgen levels.
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References
Chauhan A, Sahu JK, Jaiswal N, et al. Prevalence of autism spectrum disorder in Indian children: a systematic review and meta-analysis. Neurol India. 2019;67:100–4.
Gulati S, Kaushik JS, Saini L, et al. Development and validation of DSM-5 based diagnostic tool for children with autism spectrum disorder. PLoS One. 2019;14:e0213242.
Patra S, Kar SK. Autism spectrum disorder in India: a scoping review. Int Rev Psychiatry. 2021;33:81–112.
Ferri SL, Abel T, Brodkin ES. Sex differences in autism spectrum disorder: a review. Curr Psychiatry Rep. 2018;20:9.
Baron-Cohen S, Auyeung B, Nørgaard-Pedersen B, et al. Elevated fetal steroidogenic activity in autism. Mol Psychiatry. 2015;20:369–76.
Janšáková K, Hill M, Čelárová D, et al. Alteration of the steroidogenesis in boys with autism spectrum disorders. Transl Psychiatry. 2020;10:340.
Geier DA, Geier MR. A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Neuro Endocrinol Lett. 2007;28:565–73.
Croonenberghs J, Van Grieken S, Wauters A, et al. Serum testosterone concentration in male autistic youngsters. Neuro Endocrinol Lett. 2010;31:483–8.
El-Baz F, Hamza RT, Ayad MS, Mahmoud NH. Hyperandrogenemia in male autistic children and adolescents: relation to disease severity. Int J Adolesc Med Health. 2014;26:79–84.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. Arlington, VA. 2013. Available at: http://repository.poltekkes-kaltim.ac.id. Accessed on 22 July 2021.
Acknowledgements
The authors acknowledge all families and children who participated in the study.
Funding
PGIMER thesis grant, PGI/RGC/2015–16.
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N Sriram: Study design, data collection, data analysis, data interpretation, manuscript writing, and approval of manuscript; P Madaan: Data analysis, data interpretation, writing of initial draft, and approval of manuscript; P Malhi, PS, RK, N Sachdeva: Study design, data interpretation, and approval of manuscript; SN, JD: Data collection, data analysis, approval of manuscript; JKS: Conceptualization of study and design, data interpretation, manuscript writing, and approval of manuscript. JKS will act as the guarantor for this paper.
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Sriram, N., Madaan, P., Malhi, P. et al. Evaluation of Hyperandrogenism in Children with Autism Spectrum Disorder. Indian J Pediatr 89, 717–719 (2022). https://doi.org/10.1007/s12098-022-04080-9
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DOI: https://doi.org/10.1007/s12098-022-04080-9