Abstract
Bladder dysfunction in children is common, the most frequent underlying causes are neurologic bladder (NB), dysfunctional voiding syndrome (DVS), and the valve bladder syndrome (VBS). The aim of this study was to determine the 10-y survival rate and the associated morbidities in children with bladder dysfunction. One hundred ninety-nine children were included in the study; 60 with VBS, 75 DVS, and 64 NB. The mean age was 44 mo (CI: 37–50.9) and mean GFR 50.1 (CI 44.6–55.6) mL/min/1.73m2. The 10-y survival rate was 89%. Compared with patients with VBS, the mortality was 11 times higher among patients with NB (p = 0.02) but not significantly higher than patients with DVS (p = 0.2). GFR < 15 mL/min/1.73 m2 increases mortality rate by 6 times compared with normal GFR (p = 0.007). Late age at presentation (> 5 y) increases mortality risk and/or the need for renal replacement therapy (RRT) by almost 5 times (p = 0.013). It was concluded that the etiology of bladder dysfunction, baseline GFR, and the age at presentation significantly influence the survival rate and morbidities.
References
Farhat W, Bägli DJ, Capolicchio G, et al. The dysfunctional voiding scoring system: quantitative standardization of dysfunctional voiding symptoms in children. J Urol. 2000;164:1011–5.
Schwartz GJ, Muñoz A, Schneider MF, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20:629–37.
Herbst KW, Tomlinson P, Lockwood G, Mosha MH, Wang Z, D’Alessandri-Silva C. Survival and kidney outcomes of children with an early diagnosis of posterior urethral valves. Clin J Am Soc Nephrol. 2019;14:1572–80.
Dorsher PT, McIntosh PM. Neurogenic bladder. Adv Urol. 2012;2012:816274.
Lapides J, Diokno AC, Silber SJ, Lowe BS. Clean, intermittent self-catheterization in the ureatment of Urinary tract disease. J Urol. 2017;197:S122–4.
Husmann DA. Long-term complications following bladder augmentations in patients with spina bifida: bladder calculi, perforation of the augmented bladder and upper tract deterioration. Transl Androl Urol. 2016;5:3–11.
Sturm RM, Cheng EY. The management of the pediatric neurogenic bladder. Curr Bladder Dysfunct Rep. 2016;11:225–33.
Mehta S, Hill D, McIntyre A, et al. Meta-analysis of botulinum toxin A detrusor injections in the treatment of neurogenic detrusor overactivity after spinal cord injury. Arch Phys Med Rehabil. 2013;94:1473–81.
Leonardo CR, Filgueiras MF, Vasconcelos MM, et al. Risk factors for renal scarring in children and adolescents with lower urinary tract dysfunction. Pediatr Nephrol. 2007;22:1891–6.
Acknowledgements
The authors would like to thank Ms. Layla Abdullah for helping in data collection and statistical analyses.
Author information
Authors and Affiliations
Contributions
SE-D wrote the manuscript, helped in data collection; MB took care of surgical part comments, discussion, helped in surgical data collection; KK took care of radiological part comment, helped in data collection; AA took care of statistical part; JK distributed roll for each member of the team revision and correction of the manuscript and is the guarantor for this paper.
Corresponding author
Ethics declarations
Ethics Approval
The study design was approved by the appropriate ethics review board.
Informed Consent
Obtaining informed consent was waived as the study was retrospective and anonymous.
Conflict of Interest
None.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
El-Desoky, S.M., Banakhar, M., Khashoggi, K. et al. Outcome of Urinary Bladder Dysfunction in Children. Indian J Pediatr 89, 67–70 (2022). https://doi.org/10.1007/s12098-021-03926-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-021-03926-y