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Immunoglobulins and Lymphocyte Subsets in Children with Infantile Tremor Syndrome

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Abstract

In this hospital-based, cross-sectional study, immunoglobulin levels and lymphocyte subsets status were evaluated in children with infantile tremor syndrome (ITS) [neurocutaneous infantile B12 deficiency (NIB) syndrome]. Blood samples were drawn at the baseline (n = 28) and at 6 wk (n = 25) after treatment. A low IgG/IgA or IgM was more likely in untreated children than post-treatment (p = 0.0368). Low B cells were observed in 9 (36%), low T cells in 5 (20%), and low NK cells in 2 patients. T cell subset analysis showed low CD4 + helper T cells in 5 (20%) and low CD8 + cytotoxic T cells in 2 patients. Abnormally low percentage of low B cell/T cells/NK cells was more likely in untreated children than post-treatment (p = 0.0165). In conclusion, a proportion of children with ITS have changes in immunoglobulin and T cell subsets not consistent with any clearly defined immune abnormality, and not all such changes revert at 6 wk.

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References

  1. Chaudhary H, Verma S, Bhatia P, Vaidya PC, Singhi P, Sankhyan N. Infantile Tremor syndrome or a neurocutaneous infantile B12 deficiency (NIB) syndrome? Indian J Pediatr. 2020;87:179–84.

    Article  Google Scholar 

  2. Tamura J, Kubota K, Murakami H, et al. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol. 1999;116:28–32.

    Article  CAS  Google Scholar 

  3. Sakane T, Takada S, Kotani H, Tsunematsu T. Effects of methyl-B12 on the in vitro immune functions of human T lymphocytes. J Clin Immunol. 1982;2:101–9.

    Article  CAS  Google Scholar 

  4. Picard C, Al-Herz W, Bousfiha A, et al. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency 2015. J Clin Immunol. 2015;35:696–726.

    Article  CAS  Google Scholar 

  5. Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007;98(Suppl 1):S29-35.

    Article  CAS  Google Scholar 

  6. Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368:2041–2.

    Article  CAS  Google Scholar 

  7. Todorova T, Ermenlieva N, Tsankova G. Vitamin B12: Could it be a promising immunotherapy? In: Immunotherapy - myths, reality, ideas, future. IntechOpen. 2017. Available at: https://www.intechopen.com/books/immunotherapy-myths-reality-ideas-future/vitamin-b12-could-it-be-a-promising-immunotherapy. Accessed on 6 June 2020.

  8. Goraya JS, Kaur S. Infantile tremor syndrome – down but not out. Indian Pediatr. 2015;52:249–50.

    Article  Google Scholar 

  9. Gautam P, Sharma N, Chaudhary S, Kaushal A. Infantile tremor syndrome in modern times. J Pediatr Neurosci. 2017;12:232–6.

    Article  Google Scholar 

  10. Francis DT, Verma S, Bhatia P, Vaidya PC, Sankhyan N. Trace Element Status in Children with Infantile Tremor Syndrome: An Inductively Coupled Plasma-Mass Spectrometry Based Study. Indian J Pediatr. 2020;87:221–3.

    Article  Google Scholar 

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Acknowledgements

The authors acknowledge the assistance of Mr. Ravinder Garg (Senior Technical Officer) in the analysis of the samples.

Funding

Supported by funding from the Institute Thesis Grant. PGIMER Institute thesis grant.

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Authors and Affiliations

  1. Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India

    Amanpreet Kaur, Himanshi Chaudhary, Amit Rawat, Jitendra Kumar Sahu, Prateek Bhatia, Savita Verma & Naveen Sankhyan

Authors
  1. Amanpreet Kaur
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  2. Himanshi Chaudhary
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  3. Amit Rawat
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  4. Jitendra Kumar Sahu
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  5. Prateek Bhatia
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  6. Savita Verma
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  7. Naveen Sankhyan
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Contributions

The study was planned by AR, JKS, PB, SV, and NS. HC was involved in data interpretation, manuscript drafting, and then manuscript revision. Data collection was carried out by AK under supervision of AR, JKS, PB, SV, and NS. All authors were involved in analysis of the data and writing of the manuscript. NS is the guarantor for this paper.

Corresponding author

Correspondence to Naveen Sankhyan.

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Declaration

Presented as poster at PEDICON, 56th Annual Conference of Indian Academy of Pediatrics, Mumbai, Feb 6–10, 2019.

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None.

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Kaur, A., Chaudhary, H., Rawat, A. et al. Immunoglobulins and Lymphocyte Subsets in Children with Infantile Tremor Syndrome. Indian J Pediatr 88, 1139–1141 (2021). https://doi.org/10.1007/s12098-021-03838-x

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  • DOI: https://doi.org/10.1007/s12098-021-03838-x

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