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Clinical Profile, Risk-Factors, and Outcome of Rotaviral Diarrhea and Non-rotaviral Diarrhea Among Under-Five Children at Cuttack, Odisha, India

The Indian Journal of Pediatrics volume 88, pages 84–89 (2021)Cite this article

Abstract

Objective

To understand the prevalence of rotavirus diarrhea and its associated clinical and socio-demographic characteristics.

Methods

The prospective hospital-based study was conducted at SVP Post Graduate Institute of Pediatrics and SCB Medical College, Odisha, India among children under-five years of age from April 2016 to July 2019. From all eligible children admitted at hospital, a case-report form containing information on clinical and socio-demographic characteristics was collected and an attempt was made to collect stool sample. A simple logistic regression method was used to assess factors associated with rotavirus diarrhea.

Results

Of the 1963 children, median (IQR) age was 12 (8–19) mo with a female/male ratio was 1:2.05. The prevalence of rotavirus diarrhea was 36.4% (95% CI, 34.2%–38.6%). Children in the age group of 6–11 (OR 1.64, 95% CI, 1.24–2.18), 12–23 (OR 1.73, 95% CI, 1.31–2.29) mo had higher odds of getting rotavirus diarrhea, compared to those in that of 24–59 mo. The prevalence of wasting, stunting, underweight among children with rotavirus diarrhea was 25.2% (95% CI, 22%–28.4%), 2.1% (95% CI, 1.1%–3.1%), 9.0% (95% CI, 6.8%–11.2%), respectively.

Conclusion

The results of this study confirmed that diarrhea remains an important cause of hospitalization in children. Further studies are required in the community for Rotavirus and its genotyping.

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Acknowledgements

The authors are grateful for the co-operation by all participants, parents/guardians and surveillance staff at all the sentinel hospitals.

Funding

The funding for this project is from Bill and Melinda Gates Foundation to the Translational Health Science and Technology Institute (OPP1165083) and the CDC Foundation, Atlanta with the Christian Medical College (CMC), Vellore as sub-awardee.

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Affiliations

  1. Department of Pediatrics, Sardar Vallabhbhai Patel Post Graduate Institute of Pediatrics (SVPPGIP) & SCB Medical College, Cuttack, Odisha, India

    Subal Kumar Pradhan, Pooja Sagar Padhi & Saroj Kumar Satpathy

  2. Department of Pediatrics, Pandit Raghunath Murmu Government Medical College and Hospital, Baripada, Odisha, India

    Sumanta Panigrahi

  3. The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India

    Arjun Sajeev, Aravind Dharmaraj & Samarasimha Reddy N

Authors
  1. Subal Kumar Pradhan
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  2. Sumanta Panigrahi
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  3. Pooja Sagar Padhi
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  4. Arjun Sajeev
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  5. Aravind Dharmaraj
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  6. Samarasimha Reddy N
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  7. Saroj Kumar Satpathy
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Contributions

SKP and SP design of the study and wrote the first draft. PSP collected the data, AD and AS have analyzed the data. SRN and SKS reviewed and edited the manuscript. All authors read and approved the final manuscript. SKS will act as guarantor for this paper.

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Correspondence to Subal Kumar Pradhan.

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Pradhan, S.K., Panigrahi, S., Padhi, P.S. et al. Clinical Profile, Risk-Factors, and Outcome of Rotaviral Diarrhea and Non-rotaviral Diarrhea Among Under-Five Children at Cuttack, Odisha, India. Indian J Pediatr 88, 84–89 (2021). https://doi.org/10.1007/s12098-020-03598-0

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  • DOI: https://doi.org/10.1007/s12098-020-03598-0

Keywords

  • Rotavirus
  • Diarrhea
  • Clinical profile
  • Risk factors