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Comparison of Bilateral Cerebro-Renal Tissue Oxygenations in Healthy Children

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Abstract

Objective

To investigate right and left cerebral tissue (ctSO2) and renal tissue oxygenations (rtSO2) in otherwise healthy children.

Methods

In this observational cross-sectional study, one hundred children seen as outpatients for well child care or common non-critical complaints, were included. Bilateral ctSO2 and rtSO2 were recorded simultaneously with INVOS™ 5100 device.

Results

The median age was 6.7 y (IQR 3–10.4) and median weight was 21 kg (IQR 13–33). Right and left sided ctSO2 and rtSO2 values were 78.7% ± 6.0% and 79.1% ± 5.7%; 81.5% ± 9.4% and 81.4% ± 9.5% respectively. There were no differences in right and left cerebral and renal near infrared spectroscopy (NIRS) values, and no age centered lateralization effect. Renal measurements were higher than cerebral counterparts in 63% of the children. Interaction between age and regional oxygenation was significant. For both sides, renal oxygenation was higher than that of cerebrum in older children, whereas the opposite held true with younger age.

Conclusions

There are no right and left side differences in ctSO2 and rtSO2 values in otherwise healthy children. On the other hand, there seem to be differences between cerebral and renal regions with a significant age effect. Acknowledging its limitations, this study sheds light on laterality and cranial and renal NIRS measurements in otherwise healthy children, and may contribute to the interpretation of NIRS data in critically ill patients.

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Acknowledgements

The authors thank Dr. Esra Akdeniz for detailed statistical analysis of this study and Alp T Ozturk for careful review of the manuscript.

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Authors and Affiliations

  1. Division of Pediatric Critical Care, Department of Pediatrics, Marmara University School of Medicine, Marmara University Pendik Training and Research Hospital, Fevzi Cakmak Mah, Mimar Sinan Cad, No 41 Ust Kaynarca Pendik, 34889, Pendik, İstanbul, Turkey

    Nilüfer Yalındağ Öztürk, Burcu Aygün, Emel Uyar & Feyza İnceköy Girgin

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  1. Nilüfer Yalındağ Öztürk
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  2. Burcu Aygün
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  3. Emel Uyar
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  4. Feyza İnceköy Girgin
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Contributions

NYO designed the experiment; BA performed the experiments; NYO, FIG, EU and BA analyzed the data; FIG, EU, BA and NYO did literature search and wrote the paper. Dr. Makbule Nilufer Ozturk, Department of Pediatrics, Division of Pediatric Critical Care, Marmara University Pendik Training and Research Hospital will act as guarantor for this paper.

Corresponding author

Correspondence to Nilüfer Yalındağ Öztürk.

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None.

Source of Funding

The study is supported via an intramural grant (Marmara University Scientific Project Support BAPKO #SAG-CTUP-100616-0255).

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Öztürk, N.Y., Aygün, B., Uyar, E. et al. Comparison of Bilateral Cerebro-Renal Tissue Oxygenations in Healthy Children. Indian J Pediatr 87, 99–104 (2020). https://doi.org/10.1007/s12098-019-03093-1

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  • DOI: https://doi.org/10.1007/s12098-019-03093-1

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