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CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders

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Abstract

The ability to precisely change the deoxyribonucleic acid (DNA) bases at specific sites offers tremendous advantages in the field of molecular biology and medical biotechnology. Identification of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), revelation of its role in prokaryotic adaptive immunity and subsequent conversion into genome and epigenome engineering system are the landmark research progresses of the decade. The possibilities of deciphering the molecular mechanisms of the disease, identifying the disease targets, generating the disease models, validating the drug targets, developing resistance to the infection and correcting the genotype have brought off much enthusiasm in the field of infectious diseases and genetic disorders. This review focuses on CRISPR/Cas9’s impact in the field of infection and genetic disorders.

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Authors and Affiliations

  1. CSIR Institute for Genomics and Integrative Biology (IGIB), Mathura Road, Sukhdev Vihar, New Delhi, India

    Sivaprakash Ramalingam

  2. Center for Stem Cell Research (CSCR), A Unit of inStem Bengaluru, Christian Medical College Campus, Vellore, Tamil Nadu, India

    Saravanabhavan Thangavel

Authors
  1. Sivaprakash Ramalingam
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  2. Saravanabhavan Thangavel
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Contributions

SR and ST wrote the manuscript. SR is the guarantor for this paper.

Corresponding authors

Correspondence to Sivaprakash Ramalingam or Saravanabhavan Thangavel.

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Source of Funding

SR acknowledges Department of Biotechnology for the financial support. ST is supported by SERB (ECR/2015/000570) and Department of biotechnology (BT/PR26901/MED/31/377/2017).

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Ramalingam, S., Thangavel, S. CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders. Indian J Pediatr 86, 1131–1135 (2019). https://doi.org/10.1007/s12098-019-03037-9

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  • DOI: https://doi.org/10.1007/s12098-019-03037-9

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