Effect of Vitamin D Supplementation in the Prevention of Recurrent Pneumonia in Under-Five Children
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To assess the effect of vitamin D supplementation in the prevention of recurrent pneumonia in under-five children.
The present one year 8 months longitudinal, community-based randomized controlled study included a total of 100 under-five children with pneumonia. Children were divided into two groups: intervention group (Group I: standard treatment with vitamin D 300,000 IU; n = 50) and control group (Group C: standard treatment only; n = 50). As nine samples were hemolyzed, groups I and C comprised of 46 and 45 children, respectively. The children were followed up for 1 y and signs of upper respiratory tract infections (URTI), lower respiratory tract infections (LRTI), vitamin D deficiency, and vitamin D toxicity were recorded.
The male to female ratio in group C and I was 1.27:1 and 1.5:1, respectively (P = 0.420). Age, gender, birth, anthropometric and clinical characteristics, and feeding habits were not statistically significant (P > 0.05) between both the cohorts (Group C and I). Children with reduced vitamin D levels were high in group C (25) when compared to the group I (15). During all the follow-ups, the URTI and LRTI episodes, severity of pneumonia, number of hospital admissions, complications, mean episodes of LRTI, and mean duration of LRTI were comparable between group I and group C (P > 0.05).
Overall, the present study highlights that oral vitamin D (300,000 IU bolus dose quarterly) has some beneficial effect in the prevention of recurrent pneumonia in under-five children, although, not to a significant degree. Hence, it is recommended that further studies are required to demonstrate a significant effect of vitamin D in the prevention of pneumonia.
KeywordsLower respiratory tract infections Recurrent pneumonia Upper respiratory tract infections Vitamin D Under-five children
NS, DK, and NSM: Conceptualized the study; NS: Collected the data, literature search, and developed the manuscript; DK and NS: Analysis of data and literature search; DK and NSM: Overall supervision and intellectual input in final drafting. All authors contributed to the critical revision of the manuscript. DK is the guarantor for this article.
Compliance with Ethical Standards
Conflict of Interest
- 3.Mathyssen C, Gayan-Ramirez G, Bouillon R, Janssens W. Vitamin D supplementation in respiratory diseases: evidence from randomized controlled trials. Pol Arch Intern Med. 2017;127:775–84.Google Scholar
- 6.Rajshekhar CS, Vanaki R, Badakali AV, Pol RR, Yelamali BC. Efficacy of vitamin D supplementation in the treatment of severe pneumonia in children aged less than five years. Int J Contemp Pediatr. 2016;3:96–9.Google Scholar
- 13.Kuragodiyavar MD. Risk factors for severe pneumonia in under five children-a hospital based study: RGUHS; 2009. p. 91–3.Google Scholar
- 15.Oduwole A, Renner JK, Disu E, Ibitoye E, Emokpae E. Relationship between vitamin D levels and outcome of pneumonia in children. West Afr J Med. 2010;29:373–8.Google Scholar
- 18.Rijal P, Sharma A, Shrestha S, Upadhyay S. Profile of acute lower respiratory tract infection in children under fourteen years of age at Nepal medical college teaching hospital (NMCTH). Nepal Med Coll J. 2011;13:58–61.Google Scholar
- 20.Siddiqui TS, Rai MI. Presentation and predisposing factors of nutritional rickets in children of Hazara division. J Ayub Med Coll Abbottabad. 2005;17:29–32.Google Scholar