Effects of Exercise Intervention Program on Bone Mineral Accretion in Children and Adolescents with Cystic Fibrosis: A Randomized Controlled Trial

  • Sumita Gupta
  • Aparna Mukherjee
  • Rakesh Lodha
  • Madhulika Kabra
  • Kishore K. Deepak
  • Rajesh Khadgawat
  • Anjana Talwar
  • Sushil Kumar KabraEmail author
Original Article



To evaluate effect of one year exercise intervention program on bone mineral accrual in children and adolescent with cystic fibrosis (CF).


Fifty-two CF children (mean age 149.79 mo) were randomized into experimental (15 boys and 10 girls) and control groups (15 boys and 12 girls). Experimental group performed prescribed exercises three times/week, while control group continued with routine physical activities for one year. Following were assessed at baseline and at one year: Bone mineral density (BMD) of whole body and lumbar spine, pulmonary function, exercise capacity, quality of life and habitual activity.


Change in whole body and lumbar spine BMD over 12 mo in experimental group was lower by 0.006 g/cm2 (95% CI -0.02 to 0.02) and higher by 0.001 g/cm2 (95% CI -0.04 to 0.03) than controls, respectively. However, difference between groups was non-significant for both parameters. Experimental group had a significant improvement in their exercise capacity (p = 0.006), quality of life, and serum vitamin D (p = 0.007) levels. Differences between groups for changes in pulmonary function and habitual activity were non-significant.


Exercise regime was not associated with significant improvement in BMD of CF patients, but it had a positive impact on both physical and psychological health of these patients.


Bone mineral density Cystic fibrosis Exercise Exercise capacity Quality of life Vitamin D 



The authors would like to offer our humble thanks to all the children and their parents for having faith in them, for participating in the study and for making it on all the scheduled visits, in-spite of all odds.

Authors’ Contribution

SG: Developed the protocol, collected the data and wrote the manuscript; AM, RL, MK, KKD, RK, AT: Helped in carrying out the study, review of data and manuscript writing; SKK: Protocol development, monitoring of study and helped in manuscript writing. SKK will act as guarantor for this paper.

Compliance with Ethical Standards

Ethical Approval

All procedures performed in the study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from parents or the legal guardians of all individual participants included in the study.

Conflict of Interest


Supplementary material

12098_2019_3019_MOESM1_ESM.docx (52 kb)
ESM 1 (DOCX 52 kb)


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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Sumita Gupta
    • 1
  • Aparna Mukherjee
    • 1
  • Rakesh Lodha
    • 1
  • Madhulika Kabra
    • 1
  • Kishore K. Deepak
    • 2
  • Rajesh Khadgawat
    • 3
  • Anjana Talwar
    • 2
  • Sushil Kumar Kabra
    • 1
    Email author
  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of PhysiologyAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Department of EndocrinologyAll India Institute of Medical SciencesNew DelhiIndia

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