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Little Children, Bigger Problems: Anti-N-Methyl D-Aspartate Receptor Encephalitis!

  • Ashwini Prithvi
  • Shivan Kesavan
  • Arushi Gahlot SainiEmail author
  • Renu Suthar
  • Anita Mahadevan
Clinical Brief
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Abstract

Anti N-methyl D-aspartate receptor (NMDAR) antibody positive autoimmune encephalitis is a well-described entity both in adults as well as in children. The authors report an 18-mo-old boy who presented with seizures, movement disorder, cognitive impairment, and behavioral disturbances. Anti-NMDAR encephalitis was confirmed by detection of NMDAR antibodies in the cerebrospinal fluid. The patient was administered pulse corticosteroids and intravenous immunoglobulin followed by further immunomodulatory therapy. No tumor was detected on screening. The child remained unresponsive to treatment. The authors wish to highlight the occurrence of anti-NMDAR encephalitis in young toddlers and the poor response to therapy often seen in very young children.

Keywords

Anti-N-methyl D-aspartate NMDAR Autoimmune encephalitis Infant Encephalitis 

Notes

Acknowledgements

The authors would like to acknowledge Dr. Naveen Sankhyan and Dr. S. Bhanudeep for their help in patient management.

Authors’ Contribution

AP, SK: Original draft of the manuscript; AGS, RS: Final revision of the manuscript; AM: Analysis of the antibody profile and approval of final version of the manuscript. Dr. Naveen Sankhyan, Head, Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  • Ashwini Prithvi
    • 1
  • Shivan Kesavan
    • 1
  • Arushi Gahlot Saini
    • 1
    Email author
  • Renu Suthar
    • 1
  • Anita Mahadevan
    • 2
  1. 1.Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics CentrePost Graduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia
  2. 2.Department of NeuropathologyNational Institute of Mental Health and NeurosciencesBangaloreIndia

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