Does Food Allergy Require Any Change in Measles-Mumps-Rubella Vaccination?

  • Gizem Kara ElitokEmail author
  • Ezgi Çelikboya
  • Lida Bulbul
  • Ayşenur Kaya
  • Türkan Toraman
  • Ali Bulbul
  • Sinan Uslu
Original Article



To determine the allergic reactions that develop after Measles and Measles-Mumps-Rubella (MMR) vaccination, and whether any delay in the timing of vaccination occurs in children with food allergy.


Children with food allergy who were admitted to the Şişli Hamidiye Etfal Training and Research Hospital Healthy Child Clinic between 1st January 2015 and 30th June 2018 for Measles or MMR vaccination were studied retrospectively. Their age, delayed days of vaccination, the types of allergic food, the results of the specific IgE and skin tests, and any reaction after the vaccination were recorded.


During the study period, 159 patients were vaccinated and 170 doses of Measles or MMR vaccine were administered. Children allergic to egg were 50.3%, allergic to egg and milk were 25.8%, and 13.2% had multiple food allergy including egg. The rate of post-vaccination reactions in the patients with food allergy was 1.76%. Minor reaction was observed in three patients and no anaphylaxis was seen in any patient. Delayed days of vaccination in the patients referred by another center were greater than followed-up by present clinic (p < 0.001).


Any serious allergic reaction was not observed in this study. Food allergy does not necessitate modification of routine vaccination. Anaphylaxis may develop in any vaccinated child regardless of whether he/she has food allergy or not. Therefore, vaccines should be administered in a healthcare facility that can treat anaphylaxis.


Allergy Anaphylaxis Child Vaccination 


Authors’ Contribution

GKE: Prepared the concept of the study, designed the study, and wrote the manuscript; EÇ: Data collection, initial analysis and final submission of the manuscript; LB and AK: Design and revision of manuscript; TT: Data collection; AB and SU: Analysis, interpretation and supervised the study. AB will act as guarantor for this paper.

Compliance with Ethical Standards

Ethics Commitee Approval

This study was approved by the Şişli Hamidiye Etfal Education and Research Hospital Ethics Committee (1045/2018).

Conflict of Interest



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Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Department of PediatricsŞişli Hamidiye Etfal Education and Research HospitalSarıyer/İstanbulTurkey
  2. 2.Department of PediatricsTuzla State HospitalIstanbulTurkey
  3. 3.Department of PediatricsBakırköy Sadi Konuk Education and Research HospitalIstanbulTurkey
  4. 4.Department of Pediatrics Allergy and İmmunologyİstinye University HospitalIstanbulTurkey

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