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The Indian Journal of Pediatrics

, Volume 86, Issue 8, pp 750–750 | Cite as

Escherichia coli O157 Enterocolitis Followed by Non-diarrheagenic Escherichia coli Bacteremia

  • Hiroki KatoEmail author
  • Hiroshi Yamaguchi
  • Yusuke Ito
  • Naoko Imuta
  • Junichiro Nishi
  • Masashi Kasai
Scientific Letter
  • 367 Downloads

To the Editor: Escherichia coli (E. coli) O157 is part of the verotoxin-producing E. coli (VTEC) strains, and a causative pathogen of bacterial enterocolitis in children. VTEC also causes hemolytic uremic syndrome (HUS). However, serious bacterial infections due to VTEC have rarely been reported [1]. A previously healthy, 3-y-old boy presented with a 3 d history of abdominal pain and frequent bloody diarrhea. On admission, his general condition was stable and abdominal ultrasound indicated an extensive edematous colon. VTEC O157 was detected on stool culture. Based on these reports, bacterial enterocolitis was diagnosed. Because use of antibiotics might increase the risk of developing HUS, the patient was closely monitored without antibiotic treatment [2]. Meanwhile, his symptoms improved and bloody diarrhea stopped 7 d after admission but he continued to have mild diarrhea. However, fever recurred after 11 d, accompanied by tachycardia. The cause of fever could not be detected through examination and laboratory investigations including cerebrospinal fluid and urine test. Under suspicion of bacteremia, two blood samples were sent for culture and intravenous cefotaxime was administered. Later, the two blood culture samples detected E. coli which was sensitive to ampicillin. The PCR assay detected serotype O18:K1:H4/ST357 and no virulence factor genes for diarrheagenic E. coli, including VTEC, in these samples. Finally, we diagnosed the patient as having E. coli O157 enterocolitis, followed by non-diarrheagenic E. coli O18:K1:H4/ST357 bacteremia, due to bacterial translocation. The antibiotic was changed to a 2 wk course of ampicillin and he was discharged without sequelae. This case differs from previous cases in that bacteremia can be a complication of E. coli O157 enterocolitis even after bloody diarrhea has stopped. Although a few cases of VTEC with bacteremia have been reported earlier, they occurred during the acute phase of VTEC infections, unlike in our patient and developed HUS [1, 3, 4]. In addition, the causative organisms for bacteremia and enterocolitis were different.

Non-diarrheagenic E. coli O18:K1:H4/ST357 bacteremia may be explained by bacterial translocation-induced prolonged diarrhea. Blood culture is important if E. coli O157 enterocolitis patients develop fever without an apparent focus of infection in order to diagnose bacteremia due to bacterial translocation.

Notes

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Conflict of Interest

None.

References

  1. 1.
    Lienemann T, Salo E, Rimhanen-Finne R, et al. Shiga toxin-producing Escherichia coli serotype O78:H (−) in family, Finland, 2009. Emerg Infect Dis. 2012;18:577–81.CrossRefGoogle Scholar
  2. 2.
    Freedman SB, Xie J, Neufeld MS, et al. Shiga toxin-producing Escherichia coli infection, antibiotics, and risk of developing hemolytic uremic syndrome: a meta-analysis. Clin Infect Dis. 2016;62:1251–8.CrossRefGoogle Scholar
  3. 3.
    Chiurchiu C, Firrincieli A, Santostefano M, Fusaroli M, Remuzzi G, Ruggenenti P. Adult nondiarrhea hemolytic uremic syndrome associated with Shigatoxin Escherichia coli O157:H7 bacteremia and urinary tract infection. Am J Kidney Dis. 2003;41:E4.CrossRefGoogle Scholar
  4. 4.
    Buvens G, De Rauw K, Roisin S, et al. Verocytotoxin-producing Escherichia coli O128ab:H2 bacteremia in a 27-year-old male with hemolytic-uremic syndrome. J Clin Microbiol. 2013;51:1633–5.CrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2019

Authors and Affiliations

  1. 1.Department of PediatricsKobe City Medical Center General HospitalKobeJapan
  2. 2.Department of Infectious Disease MedicineHyogo Prefectural Kobe Children’s HospitalKobeJapan
  3. 3.Department of MicrobiologyKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

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