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Pharmacokinetics of First-Line Anti-Tubercular Drugs

  • Review Article
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Abstract

Determining the optimal dosages of isoniazid, rifampicin, pyrazinamide and ethambutol in children is necessary to obtain therapeutic serum concentrations of these drugs. Revised dosages have improved the exposure of 1st line anti-tubercular drugs to some extent; there is still scope for modification of the dosages to achieve exposures which can lead to favourable outcome of the disease. High dose of rifampicin is being investigated in clinical trials in adults with some benefit; studies are required in children. Inter-individual pharmacokinetic variability and the effect of age, nutritional status, Human immunodeficiency virus (HIV) infection, acetylator genotype may need to be accounted for in striving for the dosages best suited for an individual.

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  1. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India

    Aparna Mukherjee, Rakesh Lodha & S. K. Kabra

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AM performed the literature search, drafted the manuscript. All authors were involved in writing the review manuscript. RL will act as guarantor for this paper.

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Correspondence to Rakesh Lodha.

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Mukherjee, A., Lodha, R. & Kabra, S.K. Pharmacokinetics of First-Line Anti-Tubercular Drugs. Indian J Pediatr 86, 468–478 (2019). https://doi.org/10.1007/s12098-019-02911-w

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