The Indian Journal of Pediatrics

, Volume 86, Issue 2, pp 165–170 | Cite as

Corticotrophin-ACTH in Comparison to Prednisolone in West Syndrome – A Randomized Study

  • Vykuntaraju K. GowdaEmail author
  • Vindhya Narayanaswamy
  • Sanjay K. Shivappa
  • Naveen Benakappa
  • Asha Benakappa
Original Article



To compare the outcomes of adrenocorticotrophic hormone (ACTH) and Prednisolone therapy in children with West syndrome.


The study was done at a tertiary health centre for children. The pediatric neurologist at the centre enrolled children into the study based on the inclusion and exclusion criteria. They were evaluated in detail, classified according to etiologic type and then, randomly assigned into two treatment groups, either ACTH or Prednisolone. They were followed at regular intervals till 6 mo.


There was no difference between ACTH and Prednisolone groups with respect to all the outcomes measured. Cessation of spasms was achieved in 6/15 (40%) in Prednisolone group and 9/18 (50%) in ACTH group (p = 0.3906). The average time for achieving cessation was 6.9 and 8 d in ACTH and Prednisolone groups respectively (p = 0.7902). The relapse rates were 18.18 and 50% in ACTH and Prednisolone groups respectively (p = 0.28). The side-effects profile, subsequent epilepsy rates and improvement in milestones were similar in both the treatment groups.


There is no significant difference in children treated with ACTH and Prednisolone. Study results cannot be generalized due to small sample size. However, Prednisolone can be a suitable alternative to ACTH in resource poor settings.


ACTH Prednisolone West syndrome Infantile spasms 


Authors’ Contributions

VKG: Concept and designed the study; VN: Collected the data and helped in data analysis; SKS: Analyzed the data and drafted the manuscript; NB: Concept of study and supervised seizure control; AB: Edited and refined the draft. VKG will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest



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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Division of Pediatric Neurology, Department of PediatricsIndira Gandhi Institute of Child HealthBangaloreIndia
  2. 2.Department of PediatricsIndira Gandhi Institute of Child HealthBangaloreIndia

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