The Indian Journal of Pediatrics

, Volume 85, Issue 11, pp 952–953 | Cite as

Can We Reduce the Duration of Antibiotic Therapy for Neonatal Pneumonia?

  • B. Vishnu Bhat
  • B. Adhisivam
Editorial Commentary

According to World Health Organization (WHO) data (2016), neonatal mortality contributes to 46% of all Under 5 child deaths globally [1]. The major direct causes of neonatal deaths are infections, preterm birth and asphyxia. India contributes to one-fifth of global live births and more than a quarter of neonatal deaths [2]. So, globally and in the Indian perspective, focusing on strategies to prevent and treat neonatal sepsis including pneumonia is of paramount importance. It is estimated that pneumonia contributes to nearly one million neonatal deaths and an unknown number of stillbirths each year worldwide [3]. Usually, Gram negative bacilli predominate in the first week of life and Gram positive bacteria subsequently. The common organisms causing early onset pneumonia include E. coli, group B streptococcus, Klebsiella, and Coagulase-negative staphylococcus. Other bacteria like Streptococci viridans, H. influenzae, Citrobacter, Listeria monocytogenes and Candida albicanscan also...



BA: Drafted the manuscript; BVB: Critical analysis, edited the manuscript and will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest



  1. 1.
    World Health Organization. Children: reducing mortality – Key facts. Available at: Accessed on 22nd June 2018.
  2. 2.
    Sankar MJ, Neogi SB, Sharma J, et al. State of newborn health in India. J Perinatol. 2016;36:S3–8.CrossRefGoogle Scholar
  3. 3.
    Duke T. Neonatal pneumonia in developing countries. Arch Dis Child Fetal Neonatal Ed. 2005;90:F211–9.CrossRefGoogle Scholar
  4. 4.
    Hooven TA, Polin RA. Pneumonia. Semin Fetal Neonatal Med. 2017;22:206–13.CrossRefGoogle Scholar
  5. 5.
    Upadhyay A, Chawla D, Joshi P, Davis PG. Short-duration versus standard-duration antibiotic regimens for the treatment of neonatal bacterial infection (protocol). Cochrane Database Syst Rev. 2016;1:CD012063.Google Scholar
  6. 6.
    Mathur NB, Murugesan A. Comparison of four days versus seven days duration of antibiotic therapy for neonatal pneumonia: a randomized controlled trial. Indian J Pediatr. 2018;
  7. 7.
    Snapinn SM. Noninferiority trials. Curr Control Trials Cardiovasc Med. 2000;1:19–21.CrossRefGoogle Scholar
  8. 8.
    Engle WD, Jackson GL, Sendelbach D, et al. Neonatal pneumonia: comparison of 4 vs 7 days of antibiotic therapy in term and near term infants. J Perinatol. 2000;20:421–6.CrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of NeonatologyJawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)PondicherryIndia

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