Central Nervous System Infections in Children: An Ongoing Challenge!
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Central nervous system (CNS) infections are an important cause of morbidity and mortality in children. Estimated incidence of acute encephalitis syndrome in children is 10.5–13.8/100000 . The case fatality rate is 30% and neurological disabilities occur in one–third of survivors . Global burden of disease network (WHO) estimated that in 2010 meningitis caused approximately 422,900 deaths and encephalitis, 143,500 deaths .
Almost all organisms can infect the CNS; however there are distinct etiological differences in various geographical regions and in different seasons. Some pathogens are endemic, others sporadic and yet others cause epidemics. Hence the precise epidemiology of CNS infections is difficult to determine; also in many cases there are difficulties in determining an exact microbiological diagnosis particularly in resource limited countries. A recent multinational study of community acquired CNS infections found that 8.8% people died, and 18.5% were left with...
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