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Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism

  • Pavan Reddy
  • Kritika Tiwari
  • Abhishek Kulkarni
  • Ketan Parikh
  • Raju Khubchandani
Clinical Brief
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Abstract

Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed. This entity should be kept in mind in cases of ovarian cysts, especially those with isosexual precocity, to prevent unnecessary evaluation and surgical misadventures.

Keywords

Hypothyroidism Precocious puberty Ovarian mass Van Wyk Grumbach syndrome 

Notes

Author Contributions

PR: Work up of the case, followed up the case, reviewed the literature and drafted the manuscript; KT: Reviewed the literature and drafted the manuscript; AK: Work up and management of the case; KP: Diagnosis and management of the case; RK: Work up and management of the case, evaluation of manuscript and gave final approval; RK will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of PediatricsJaslok Hospital and Research CentreMumbaiIndia

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