Evaluating Liver Fibrosis by Acoustic Radiation Force Impulse in Thalassemia
To the Editor: Acoustic radiation force impulse (ARFI) is an ultrasound-based elastography technique used to evaluate tissue stiffness by virtual touch tissue quantification using a conventional probe . ARFI results strongly correlate with the stage of fibrosis in chronic liver disease, and it, therefore, promises to replace liver biopsy . There are very few studies both internationally and in India that have evaluated the use of ARFI scan in thalassemic population .
A cross-sectional, non-interventional, observational study of 84 thalassemia major patients, between 8 and 18 y of age, was performed at a tertiary hospital in Mumbai from January through December 2016. Liver stiffness was assessed on a Siemens Accuson S 3000 ARFI machine using a 2.67 MHz probe, and shear velocity were documented in meters per second (m/s). Liver stiffness measurements were taken by the same person (radiologist) to minimize inter-observer variabilities. 3 Tesla MRI T2* imaging was used for iron...
ARFI and MRI scans were sponsored by THINK Foundation, an NGO working for Thalassemia.
Compliance with Ethical Standards
Conflict of Interest
- 3.Shivaraja A, Hegde P, Bukelo MJ, Kumar PS, Basti RS. Virtual touch tissue quantification of liver in thalassemia. Int J Contemp Pediatr. 2015;2:415–8.Google Scholar