Skip to main content

Advertisement

Log in

Concepts, Utility and Limitations of Cord Blood Banking: What Clinicians Need to Know

  • Review Article
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Stem cell transplantation and cord blood banking have received much popularity among general public and medical professionals in the recent past. But information about the scientific aspects, its utility and limitations is incomplete amongst laypersons as well as many medical practitioners. Stem cells differ from all other types of cells in the human body because of their ability to multiply in order to self perpetuate and differentiate into specialized cells. Stems cells could be totipotent, multipotent, pluripotent, oligopotent or unipotent depending on the type of cells that can arise or differentiate from them. Umbilical cord blood serves as a potent source of hematopoeitic stem cells and is being used to treat various disorders like blood cancers, hemoglobinopathies and immunodeficiency disorders for which hematological stem cell transplantation is the standard of care. Cord blood can be collected at ease, without any major complications and has a lower incidence of graft vs. host reaction compared to bone marrow cells or peripheral blood cells. Both public and private banks have been established for collection and storage of umbilical cord blood. However, false claims and misleading commercial advertisements about the use of umbilical cord blood stem cells for the treatment of a variety of conditions ranging from neuromuscular disorders to cosmetic benefits are widespread and create unrealistic expectations in laypersons and clinicians. Many clinicians and laypersons are unaware of the limitations of cord blood banking, as in treating a genetic disorder by autologous cord blood transplant. Knowledge and awareness about the scientific indications of cord blood stem cell transplantation and realistic expectations about the utility of cord blood among medical practitioners are essential for providing accurate information to laypersons before they decide to preserve umbilical cord blood in private banks and thus prevent malpractice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989;321:1174–8.

    Article  PubMed  CAS  Google Scholar 

  2. Tuteja M, Agarwal M, Phadke SR. Knowledge of cord blood banking in general population and doctors: a questionnaire based survey. Indian J Pediatr. 2016;83:238–41.

    Article  PubMed  Google Scholar 

  3. Murke F, da Conceição Castro SV, Giebel B, Görgens A. Concise review: asymmetric cell divisions in stem cell biology florian. Symmetry. 2015;7:2025–37.

    Article  CAS  Google Scholar 

  4. Fisher SA, Zhang H, Doree C, Mathur A, Martin-Rendon E. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev 2015;(9):CD006536.

  5. Kułak-Bejda A, Kułak P, Bejda G, Krajewska-Kułak E, Kułak W. Stem cells therapy in cerebral palsy: a systematic review. Brain Dev. 2016;38:699–705.

    Article  PubMed  Google Scholar 

  6. Novak I, Walker K, Hunt RW, Wallace EM, Fahey M, Badawi N. Concise review: stem cell interventions for people with cerebral palsy: systematic review with meta-analysis. Stem Cells Transl Med. 2016;5:1014–25.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wang Q, Duan F, Wang MX, Wang XD, Liu P, Ma LZ. Effect of stem cell-based therapy for ischemic stroke treatment: a meta-analysis. Clin Neurol Neurosurg. 2016;146:1–11.

    Article  PubMed  Google Scholar 

  8. Sienkiewicz D, Kulak W, Okurowska-Zawada B, Paszko-Patej G, Kawnik K. Duchenne muscular dystrophy: current cell therapies. Ther Adv Neurol Disord. 2015;8:166–77.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Goel A. Stem cell therapy in spinal cord injury: hollow promise or promising science? J Craniovertebr Junction Spine. 2016;7:121–6.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Heslop JA, Hammond TG, Santeramo I, et al. Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies. Stem Cells Transl Med. 2015;4:389–400.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Gluckman E, Ruggeri A, Volt F, Cunha R, Boudjedir K, Rocha V. Milestones in umbilical cord blood transplantation. Br J Haematol. 2011;154:441–7.

    Article  PubMed  Google Scholar 

  12. Lasky LC, Lane TA, Miller JP, et al. In utero or ex utero cord blood collection: which is better? Transfusion. 2002;42:1261–7.

    Article  PubMed  Google Scholar 

  13. Ballen KK, Spitzer TR, Yeap BY, McAfee S, Dey BR, Attar E, et al. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant. 2007;13:82–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Shearer WT, Lubin BH, Cairo MS, Notarangelo LD; AAP section on hematology/oncology, AAP section on allergy and immunology. Cord blood banking for potential future transplantation. Pediatrics. 2017;140:e20172695.

    Article  PubMed  PubMed Central  Google Scholar 

  15. ACOG Committee Opinion No. 648: Umbilical cord blood banking. Obstet Gynecol. 2015;126:e127–9.

  16. ACOG Committee Opinion No. 684: Delayed umbilical cord clamping after birth. Obstet Gynecol. 2017;129:e5–10.

Download references

Contributions

DLN: Conception or design of the work, acquisition, analysis, or interpretation of data for the work and drafting the work. Final approval of the version to be published. Agreement to be accountable for all aspects of the work; SRP: Conception of the work and revising the work. Final approval of the version to be published. Agreement to be accountable for all aspects of the work. SRP will act as guarantor for this paper.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shubha R. Phadke.

Ethics declarations

Conflict of Interest

None.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Narayanan, D., Phadke, S.R. Concepts, Utility and Limitations of Cord Blood Banking: What Clinicians Need to Know. Indian J Pediatr 86, 44–48 (2019). https://doi.org/10.1007/s12098-018-2651-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-018-2651-y

Keywords

Navigation