The Indian Journal of Pediatrics

, Volume 85, Issue 5, pp 329–330 | Cite as

Economic Burden of Transfusion Dependent Thalassemia

  • V. P. ChoudhryEmail author

Beta-thalassemia is the most common autosomal recessive disorder worldwide. Several surveys have been conducted including multi-centric studies under Jai Vigyan S & T mission project on community control of thalassemia syndromes and its mean prevalence is nearly 3.5% (range 1–17%) [1, 2, 3, 4, 5]. Its prevalence is high in certain communities like Sindhis, Punjabis, Khatries, Gujratis, Mahars, Lohans and in certain Muslim and Christian communities. In India, over 50 million people are carriers of thalassemia [6]. As per National Health Mission guidelines on Hemoglobinopathies in India, 10,000 to 15,000 babies with thalassemia major are born in India every year and about 1 to 1.5 lakh thalassemia patients are there in our country [7].

Thalassemia major requires regular transfusion and chelation therapy throughout the life and has major economic burden of treatment. A large number of publications have appeared on various aspects of thalassemia management and control [8, 9] but there is...


Compliance with Ethical Standards

Conflict of Interest



  1. 1.
    Verma IC. The challenge of genetic disorders in India. Molecular Genetics and Gene Therapy- The New Frontier. Amsterdam: Scientific Communications; 1994. p. 11–20.Google Scholar
  2. 2.
    Bashyam MD, Bashyam L, Savithri GR, Gopi Krishna M, Sangal V, Devi AR. Molecular genetic analyses of beta thalassemia in South India reveal rare mutations in the beta globin gene. J Hum Genet. 2004;49:408–13.CrossRefPubMedGoogle Scholar
  3. 3.
    Gupta A, Hattori Y, Gupta UR, et al. Molecular genetic testing of beta-thalassemia patients of Indian origin and a novel 8bp deletion mutation at codons 36/37/38/39. Genet Test. 2003;7:163–8.CrossRefPubMedGoogle Scholar
  4. 4.
    PRB. World population data sheet. Washington DC: Population Reference Bureau; 2010.Google Scholar
  5. 5.
    Mohanty D, Colah R, Gorakshakar A. Jai Vigyan S and T Mission Project on Community Control of Thalassemia Syndromes – Awareness, Screening, Genetic Counselling and Prevention. Published by Director-General Indian Council Medical Research; 2008.Google Scholar
  6. 6.
    Choudhry VP, Arora JS. Thalassemia. In: Gupta P, Menon PSN, Ramji S, Lodha R, editors. PG Textbook of Pediatric. Vol 2. Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2015. p. 1556–65.Google Scholar
  7. 7.
    National Health Mission Guidelines on haemoglobinopathies in India. Prevention and control of haemoglobinopathies in India-thalassemia, sickle cell disease and other variant hemoglobins. Published by Ministry of Health & Family Welfare Government of India; 2016.Google Scholar
  8. 8.
    Verma IC, Saxena R, Kohli S. Past, present & future scenario of thalassaemic care & control in India. Indian J Med Res. 2011;134:507–21.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Grow K, Vashist M, Abrol P, Sharma S, Yadav R. Beta-thalassemia in India: current status and the challenges ahead. Int J Pharm Pharmaceu Sci. 2014;6:28–33.Google Scholar
  10. 10.
    Moirangthem A, Phadke SR. Socio-demographic profile and economic burden of treatment of transfusion dependent thalassemia. Indian J Pediatr. 2018;85:102–70.CrossRefPubMedGoogle Scholar
  11. 11.
    Shobini R. Guidelines for recovery of processing charge for blood components. NACO Guidelines. No. S. 12016/01/2012-NACO (NBTC); 2014.Google Scholar
  12. 12.
    Borgna-Pignatti C. The life of patients with thalassemia major. Haematologica. 2010;95:345–8.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Caocci G, Orofino MG, Vacca A, et al. Long-term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment. Am J Hematol. 2017;92:1303–10.CrossRefPubMedGoogle Scholar
  14. 14.
    Cappellin MD, Cohen A, Porter J, Taher A, Viprakasit V. Guidelines for the management of transfusion dependant (TDT). Thalassemia International Federation. Publication No.20; 2014.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Department of HematologyFortis Escorts HospitalFaridabadIndia
  2. 2.Batra Hospital & Medical Research CenterNew DelhiIndia
  3. 3.Department of HematologyAIIMSNew DelhiIndia

Personalised recommendations