Growth Hormone Therapy and Lipid Profile
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Recombinant Growth Hormone (GH) therapy is indicated to increase height in children with proven GH deficiency (GHD). It has also been found to benefit short children born small for gestational age (SGA) who fail to have catch-up growth by 2–4 y of age .
The effects of GH on linear growth in childhood are mediated by the secretion of Insulin-like-growth-factor-1 (IGF-1) from the liver and cartilage growth plates. Apart from this, GH has several metabolic actions in the body including those on body composition and lipid and glucose metabolism . Due to its lipolytic effect, it leads to a decrease in body fat mass and proportionate increase in lean body mass. It inhibits de novo synthesis of lipids in the liver and also activates key enzymes in lipoprotein metabolism. GH has an intricate action on glucose metabolism; on one hand, it antagonizes the effect of insulin on the muscle and liver leading to decreased insulin sensitivity and hyperglycemia, while IGF-1 has insulin-like...
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