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The Indian Journal of Pediatrics

, Volume 85, Issue 10, pp 855–860 | Cite as

Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis

  • Shun-li Cao
  • Hong Jiang
  • Shi-ping Niu
  • Xiao-hu Wang
  • Shan Du
Original Article

Abstract

Objective

To summarize the available randomized controlled trials (RCTs) to evaluate the effect of taurine supplementation on growth in low birth weight infants (LBW).

Methods

PubMed, EmBase, and Cochrane Library electronic databases were searched for published articles through March 2017. Analysis was done to examine the effect of taurine supplementation on growth, and sensitivity analysis was performed by removing each individual study from meta-analysis.

Results

Results of 9 trials totaling 216 LBW infants in the present meta-analysis were collected and analyzed. The conclusion of included studies demonstrated that taurine supplementation significantly reduced length gain (WMD:-0.18; P < 0.001), plasma glycine (WMD:-106.71; P = 0.033), alanine (WMD:-229.30; P = 0.002), leucine (WMD:-64.76; P < 0.001), tyrosine (WMD:-118.11; P < 0.001), histidine (WMD:-52.16; P < 0.001), proline (WMD: -84.29; P = 0.033), and asparagine-glutamine (WMD:-356.30; P < 0.001). However, taurine supplementation was associated with higher levels of acidic sterols (WMD:0.61; P = 0.024), total fatty acids (WMD:7.94; P = 0.050), total saturated fatty acids (WMD:9.70; P < 0.001), and unsaturated fatty acids (WMD:6.63; P < 0.001). Finally, taurine supplementation had little or no significant effect on weight gain, head circumference gain, plasma taurine, threonine, serine, citrulline, valine, methionine, isoleucine, phenylalanine, ornithine, lysine, arginine, glutamate, hydroxyproline, aspartate, dietary cholesterol, endogenous neutral sterols, cholesterol synthesis, and medium-chain triglycerides.

Conclusions

The findings suggest that although there are several significant differences in plasma indeces, no significant effect on growth in LBW infants was observed with taurine supplementation.

Keywords

Taurine supplementation Growth Low birth weight infants Meta-analysis 

Notes

Acknowledgements

The authors thank all the members of their study team for their wholehearted cooperation in this endeavor.

Contributions

SLC and HJ carried out the studies, participated in collecting the data, and drafted the manuscript. SPN and XHW performed the statistical analysis and participated in its design. SD helped to draft the manuscript. Dr. Guoqiang Cheng, Department of Neonatology, Children’s Hospital of Fudan University will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

Affilited Hospital of Qingdao University.

Supplementary material

12098_2018_2609_MOESM1_ESM.bmp (2.3 mb)
Supplementary Fig. 1 Flow diagram of the literature search and the study selection process. (BMP 2304 kb)

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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  • Shun-li Cao
    • 1
  • Hong Jiang
    • 2
  • Shi-ping Niu
    • 3
  • Xiao-hu Wang
    • 4
  • Shan Du
    • 5
  1. 1.Department of PediatricsAffiliated Hospital of Qingdao UniversityQingdaoPeople’s Republic of China
  2. 2.Department of PediatricsAffiliated Hospital of Qingdao UniversityQingdaoPeople’s Republic of China
  3. 3.Department of NeonatologyZibo Maternity and Child Health Care HospitalZiboPeople’s Republic of China
  4. 4.Department of NeonatologyZiboPeople’s Republic of China
  5. 5.Department of NeonatologyZiboPeople’s Republic of China

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