The Indian Journal of Pediatrics

, Volume 85, Issue 7, pp 493–497 | Cite as

Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy

  • Bindu Deopa
  • Manish Parakh
  • Pawan Dara
  • Vikas Payal
  • Kapil Chordiya
  • Ankit Panday
  • Sumeet Singh
  • Devesh Parashar
Original Article



To evaluate the effect of folic acid supplementation on seizure control in folate deficient children receiving long term antiepileptic therapy.


In a prospective interventional study, 140 children between age group 6 mo to 180 mo fulfilling the inclusion criteria were enrolled in study group, from October 2015 through November 2016. On the basis of serum folate, study group was divided into two subgroups by non randomization: Group A (<10 ng/ml) given folic acid supplementation for 3 mo and Group B (>10 ng/ml) was not supplemented. Response to folic acid supplementation in group A was compared with group B in terms of change in blood folate levels, frequency and duration of seizures after three months.


Mean age of study group was 73.58 ± 46.89 mo (72.14% boys and 27.85% girls). 67.85% children were in group A and 32.14% in group B. On 3 mo follow up, children supplemented with folic acid (Group A) had significant fall in mean seizure frequency while in non-supplemented children (Group B), no significant change was seen (p value <0.05). Similar reduction in duration of seizure episode was seen in group A as compared to group B. Serum and RBC folate levels improved from baseline in group A, while in group B there was significant fall in folate levels.


Folate deficiency is common in epileptic children on long term antiepileptic drugs (AEDs), contributes to poor seizure control and should be considered in the etiologic differentials of drug resistant epilepsy. Folate supplementation improves seizure control in these children.


Childhood epilepsy Folic acid Seizure Refractory 



The authors thank Dr. Pramod Sharma, Head of the Department, Dr. S. N. Medical College, Jodhpur for his support and guidance.


BD and MP conceived and designed the study. BD, MP, PD,VP, KC, AP, SS and DP reviewed the literature, analyzed and interpreted data, drafted and prepared the manuscript. MP will act as the guarantor of the study. The final manuscript was approved by all authors.

Compliance with Ethical Standards

Conflict of Interest



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Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  • Bindu Deopa
    • 1
  • Manish Parakh
    • 1
  • Pawan Dara
    • 1
  • Vikas Payal
    • 1
  • Kapil Chordiya
    • 1
  • Ankit Panday
    • 1
  • Sumeet Singh
    • 1
  • Devesh Parashar
    • 2
  1. 1.Department of PediatricsDr. S. N. Medical CollegeJodhpurIndia
  2. 2.Department of PathologyRog Nidan Seva Diagnostic CentreJodhpurIndia

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