Serum Total Magnesium Level and its Correlation with Symptom Control in Children with Mild Persistent Asthma
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To determine the prevalence of hypomagnesemia in children with mild persistent asthma and to correlate the serum magnesium levels with symptom control in the above children.
It was a cross sectional study carried out from 1st April 2015 to 31st July 2016 at the department of Pediatrics, JIPMER Hospital. Participants included six to 12-y-old children with mild persistent asthma registered at childhood asthma clinic. Pulmonary function tests were done in all children using Care fusion Jaeger spirometer. Symptom control was assessed by childhood asthma control test questionnaire and the asthma control test questionnaire (ACT) score. Serum magnesium was measured using photometric method. Proportion of children with well controlled, partially controlled and poorly controlled asthma, serum magnesium levels across the three levels of control and correlation of serum magnesium level with ACT score and pulmonary function tests were studied.
The prevalence of hypomagnesemia in children with mild persistent asthma was 5.6%. The median serum magnesium level was 2.0 mg/dl (IQR 1.9–2.1 mg/dL). As assessed by the ACT score, 66% had well controlled, 23% had partially controlled and 11% had poorly controlled asthma. There was no significant difference in the serum magnesium levels in the above three groups. There was no significant correlation between serum magnesium levels and ACT score as well as pulmonary function tests.
The prevalence of hypomagnesemia in the index study is much lower than earlier studies and there seems to be no significant association between serum magnesium levels and asthma symptom control.
KeywordsAsthma Control Child Magnesium
The authors thank the Department of Preventive and Social Medicine, JIPMER for helping them with statistical analysis. The authors also thank Davies B, Danseco E, Cicutto L, Higuchi KS, McConnell H, Edwards N, MacPherson A & Clarke D of Nursing Best Practice Research Unit, University of Ottawa, Canada for making available the Inhaler Device Assessment Tool and inspiring them to device an assessment score for rotahaler use.
All authors were involved in study design, carrying out the study, literature search, drafting of the manuscript and critically reviewing it for intellectual content. All authors have seen and approved the final draft. Prof. Niranjan Biswal, Professor Senior Scale, Department of Pediatrics, JIPMER will act as guarantor for this paper.
Compliance with Ethical Standards
Conflict of Interest
Source of Funding
This study was supported by an Intramural research grant from JIPMER (Grant No: JIP/RES/Intra-MD-MS/first/04/2014 dated 09/12/2014.
- 1.WHO | Asthma [Internet]. WHO. Available at: http://www.who.int/respiratory/asthma/en/. Accessed 30 July 2016.
- 2.Global Asthma Report 2014. pdf [Internet]. Available at: http://www.globalasthmareport.org/resources/Global_Asthma_Report_2014.pdf. Accessed 30 July 2016.
- 5.Pocket Guide for Asthma Management and Prevention 2015. pdf [Internet]. [updated 2015]. Available at: http://ginasthma.org/wp-content/uploads/2016/01/GINA_Pocket_2015.pdf. Accessed 30 July 2016.
- 10.Global Atlas of Asthma. pdf [Internet]. Available at: http://www.eaaci.org/GlobalAtlas/Global_Atlas_of_Asthma.pdf. Accessed 24 Aug 2016.
- 13.Braido F. Failure in asthma control: reasons and consequences. Scientifica [Internet]. 2013. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881662/. Accessed 30 July 2016.