Advertisement

The Indian Journal of Pediatrics

, Volume 85, Issue 3, pp 166–167 | Cite as

The Role of Zinc in Childhood Infectious Disease

  • Rohan Malik
Editorial Commentary

There has been a growing appreciation of the role of zinc in human biology. This is especially true in populations where malnutrition and deficiency of zinc is prevalent. Zinc is an essential component of enzymes, proteins and bio membranes and plays a fundamental role in cellular metabolism and immunity. In low-income settings, due to a lower dietary intake of zinc rich animal source foods in which zinc is more bioavailable and a higher consumption of cereals and legumes, which contain inhibitors of zinc absorption combined with a poor diet in general, 30–50% of children have low plasma zinc levels [1].

Levels of plasma zinc are inadequate markers of zinc deficiency and cutoff values are imperfect at best. Evidence of the role of zinc in childhood infectious disease comes from large intervention trials in diarrhea, pneumonia and malaria.

In this issue, Agarwal et al. [2] report the results of their study where serum zinc levels were measured in children presenting with acute diarrhea...

Notes

Compliance with Ethical Standards

Conflict of Interest

None.

References

  1. 1.
    Bhatnagar S, Natchu UC. Zinc in child health and disease. Indian J Pediatr. 2004;71:991–5.CrossRefPubMedGoogle Scholar
  2. 2.
    Agrawal A, Gupta NK, Upadhyay A, Soni RK, Shah D, Jaiswal V. Serum zinc levels as a predictor of severity of acute diarrhea. Indian J Pediatr. 2017;  https://doi.org/10.1007/s12098-017-2493-z.
  3. 3.
    Arora R, Kulshreshtha S, Mohan G, Singh M, Sharma P. Estimation of serum zinc and copper in children with acute diarrhea. Biol Trace Elem Res. 2006;114:121–6.CrossRefPubMedGoogle Scholar
  4. 4.
    Strand TA, Adhikari RK, Chandyo RK, Sharma PR, Sommerfelt H. Predictors of plasma zinc concentrations in children with acute diarrhea. Am J Clin Nutr. 2004;79:451–6.CrossRefPubMedGoogle Scholar
  5. 5.
    Patel A, Mamtani M, Dibley MJ, Badhoniya N, Kulkarni H. Therapeutic value of zinc supplementation in acute and persistent diarrhea: a systematic review. PLoS One. 2010;5:e10386.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Mayo-Wilson E, Junior JA, Imdad A, et al. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database Syst Rev. 2014:CD009384.  https://doi.org/10.1002/14651858.CD009384.pub2
  7. 7.
    Lamberti LM, Walker CL, Chan KY, Jian WY, Black RE. Oral zinc supplementation for the treatment of acute diarrhea in children: a systematic review and meta-analysis. Nutrients. 2013;5:4715–40.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Yakoob MY, Theodoratou E, Jabeen A, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011;11:S23.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2018

Authors and Affiliations

  1. 1.Pediatric Gastroenterology, Hepatology and Clinical Nutrition, Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations