Prevalence of Vitamin D Deficiency in Children (6–18 years) Residing in Kullu and Kangra Districts of Himachal Pradesh, India
To assess the prevalence of Vitamin D deficiency (VDD) and associated risk factors amongst children in the age group of 6–18 y residing at an altitude of 1000 mts and above.
A community based cross-sectional study was conducted in the year 2015–2016. Two districts (namely: Kangra and Kullu) of Himachal Pradesh state, India was selected for the present study. In each district thirty clusters/schools were identified using Population Proportionate to Size (PPS) sampling methodology. In the identified school, all the children in schools were enlisted. Twenty children per school were selected by using random number tables. A total of 1222 children (Kangra: 610; Kullu: 612) in the age group of 6–18 y were enrolled. The data on socio economic status, physical activity and sunlight exposure was collected. The blood samples were collected and serum 25-hydroxyvitamin D, intact parathyroid hormone, serum calcium, phosphorous, albumin and alkaline phosphate were assessed using standard procedures.
Eighty one percent (Kangra) and 80.0% (Kullu) of school age children were found Vitamin D deficient as per serum 25(OH) D levels (less than 20 ng/ml).
A high prevalence of VDD was found in children residing in 2 districts located at high altitude regions of Himachal Pradesh, India.
KeywordsVitamin D deficiency Parathyroid hormone Children India
UK: Concept, design, literature search, data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing and manuscript review; RMP: Concept, design, data analysis, statistical analysis and manuscript review; BS: Concept, design, data acquisition, manuscript editing and manuscript review; LR: Concept, design, literature search, data acquisition, data analysis, manuscript editing and manuscript review; NS: Literature search, data acquisition and manuscript review; GS: Literature search manuscript editing and manuscript review; NehaS: Literature search, manuscript preparation, manuscript editing and manuscript review. UK will act as guarantor for this paper.
Compliance with Ethical Standards
Conflict of Interest
Source of Funding
The Project was supported by Department of Biotechnology, Government of India (vide letter no: BT/PR6701/FNS/20/674/2012) for providing us the financial grant for conducting this study.
- 1.Rathi N, Rathi A. Vitamin D and child health in the 21st century. Indian Pediatr. 2011;48:619–25.Google Scholar
- 5.Sahu M, Bhatia V, Aggarwal A, et al. Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India. Clin Endocrinol. 2009;70:680–4.Google Scholar
- 10.Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79:362–71.Google Scholar
- 12.Piek E, Sleumer LS, Someren van EP, et al. Osteotranscriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis. Bone. 2010;46:613–27.Google Scholar
- 19.Bartoszewska M, Kamboj M, Patel DR. Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am. 2010;57:849–61.Google Scholar
- 24.Kapil U, Pandey RM, Goswami R, et al. Prevalence of vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India. Indian J Endocrinol Metabol. 2017;21:178–83.Google Scholar
- 25.Kumar BPR, Dudala SR, Rao AR. Kuppuswamy’s socio-economic status scale –a revision of economic parameter for 2012. Intl J Res Dev Health. 2011;1:2–4.Google Scholar
- 27.McLatchie G. Oxford Handbook of Clinical Surgery. Oxford: Oxford Medical Publications; 1990. p. 60–1.Google Scholar