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The Indian Journal of Pediatrics

, Volume 85, Issue 9, pp 790–791 | Cite as

Chronic Inflammatory Demyelinating Polyneuropathy: A Case Series

  • Arunmozhimaran Elavarasi
  • Vinay Goyal
  • Venugopalan Vishnu
  • Mamta Bhushan Singh
  • Padma Srivastava
Scientific Letter
  • 141 Downloads

To the Editor: Pediatric chronic inflammatory demyelinating polyneuropathy (PCIDP) is uncommon. There are no randomized controlled trials (RCTs) and choice of treatment is empirical based on that in adult CIDP and experience of treating physician [1]. Intravenous immunoglobulin (IVIG) and corticosteroids are the first line drugs. Plasmapheresis, azathioprine, mycophenolate mofetil, cyclophosphamide and rituximab are started if the case is refractory to IVIG or steroid dependent [2].

The course may be monophasic, acute onset resembling acute inflammatory demyelinating polyneuropathy (AIDP), subacute onset over 4–8 wk, chronic (>8 wk), multiphasic with infrequent relapses or progressive and refractory [ 2]. We discuss the course and management of one patient and summarize the rest of the patients in Table  1.
Table 1

Pediatric CIDP: clinical profile of patients

 

Patient 1

Patient 2

Patient 3

Patient 4

Age of onset, years

8

4

11

11

Sex

Male

Male

Male

Female

Onset

Acute

Acute

Insidious

Acute

Notes

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

References

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    Haliloğlu G, Yüksel D, Temuçin CM, Topaloğlu H. Challenges in pediatric chronic inflammatory demyelinating polyneuropathy. Neuromuscul Disord. 2016;26:817–24.CrossRefPubMedGoogle Scholar
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    Nevo Y, Topaloglu H. 88th ENMC International Workshop: Childhood Chronic Inflammatory Demyelinating Polyneuropathy (including revised diagnostic criteria), Naarden, The Netherlands, December 8-10, 2000. Neuromuscul Disord. 2002;12:195–200.Google Scholar
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    Ryan MM, Grattan-Smith PJ, Procopis PG, Morgan G, Ouvrier RA. Childhood chronic inflammatory demyelinating polyneuropathy: clinical course and long-term outcome. Neuromuscul Disord. 2000;10:398–406.CrossRefPubMedGoogle Scholar
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    McMillan HJ, Kang PB, Jones HR, Darras BT. Childhood chronic inflammatory demyelinating polyradiculoneuropathy: combined analysis of a large cohort and eleven published series. Neuromuscul Disord NMD. 2013;23:103–11.CrossRefPubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Arunmozhimaran Elavarasi
    • 1
  • Vinay Goyal
    • 1
  • Venugopalan Vishnu
    • 1
  • Mamta Bhushan Singh
    • 1
  • Padma Srivastava
    • 1
  1. 1.Department of NeurologyAll India Institute of Medical SciencesNew DelhiIndia

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