Childhood Brucellosis in Eastern India
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To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India.
Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted.
The findings revealed significantly higher percentage of infection in female children (14.3%) than in male children (10.9%). The positive results by different diagnostic tools, STAT, RBPT, ELISA- IgM, ELISA-IgG and brucella genus specific PCR were 10.6%, 7.2%, 7.2%, 0.85% and 1.3% respectively. Main associated clinical symptoms were joint pain, low backache, fatigue and night sweat.
This hospital based study reflects a significant number of childhood brucellosis cases in Eastern zone of India, and thus emphasizes the need for further monitoring of such subjects.
KeywordsChildhood brucellosis PUO STAT RBPT ELISA PCR
The authors hereby acknowledge the support received from all staffs of Department of Microbiology, Peerless Hospital & B. K. Roy Research Centre, Kolkata.
All the authors were involved in the study. DD performed the study protocols, analyzed the data and drafted the manuscript. SD designed the study, critically reviewed, finalized the manuscript and will act as guarantor for this paper.
Compliance with Ethical Standards
Conflict of Interest
Source of Funding
This study was funded by the Department of Biotechnology (DBT), Government of India (Grant No. & Date: 102/IFD/SAN/3141/2012–2013 dated September, 27 2012).
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