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Childhood Brucellosis in Eastern India

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The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India.

Methods

Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted.

Results

The findings revealed significantly higher percentage of infection in female children (14.3%) than in male children (10.9%). The positive results by different diagnostic tools, STAT, RBPT, ELISA- IgM, ELISA-IgG and brucella genus specific PCR were 10.6%, 7.2%, 7.2%, 0.85% and 1.3% respectively. Main associated clinical symptoms were joint pain, low backache, fatigue and night sweat.

Conclusions

This hospital based study reflects a significant number of childhood brucellosis cases in Eastern zone of India, and thus emphasizes the need for further monitoring of such subjects.

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Acknowledgements

The authors hereby acknowledge the support received from all staffs of Department of Microbiology, Peerless Hospital & B. K. Roy Research Centre, Kolkata.

Contributions

All the authors were involved in the study. DD performed the study protocols, analyzed the data and drafted the manuscript. SD designed the study, critically reviewed, finalized the manuscript and will act as guarantor for this paper.

Author information

Authors and Affiliations

  1. Brucella Research Laboratory, Peerless Hospital & B.K. Roy Research Centre, 360 Panchasayar, Kolkata, West Bengal, 700094, India

    Devarati Dutta, Prabir Kuila & Satadal Das

  2. Department of Microbiology, MGM Medical College, Kishanganj, Bihar, India

    Anindita Sen

  3. Department of Microbiology & Infection Control, CMRI and BM Birla Heart Research Centre, Kolkata, India

    Debkishore Gupta

  4. Department of Food Technology & Biochemical Engineering, Jadavpur University, Kolkata, India

    Debasmita Chatterjee

  5. Department of Laboratory, Peerless Hospital & B.K. Roy Research Centre, Kolkata, India

    Sugat Sanyal

Authors
  1. Devarati Dutta
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  2. Anindita Sen
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  3. Debkishore Gupta
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  4. Prabir Kuila
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  5. Debasmita Chatterjee
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  6. Sugat Sanyal
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  7. Satadal Das
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Corresponding author

Correspondence to Satadal Das.

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Conflict of Interest

None.

Source of Funding

This study was funded by the Department of Biotechnology (DBT), Government of India (Grant No. & Date: 102/IFD/SAN/3141/2012–2013 dated September, 27 2012).

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Cite this article

Dutta, D., Sen, A., Gupta, D. et al. Childhood Brucellosis in Eastern India. Indian J Pediatr 85, 266–271 (2018). https://doi.org/10.1007/s12098-017-2513-z

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  • DOI: https://doi.org/10.1007/s12098-017-2513-z

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