Childhood Brucellosis in Eastern India

  • Devarati Dutta
  • Anindita Sen
  • Debkishore Gupta
  • Prabir Kuila
  • Debasmita Chatterjee
  • Sugat Sanyal
  • Satadal Das
Original Article
  • 44 Downloads

Abstract

Objective

To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India.

Methods

Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted.

Results

The findings revealed significantly higher percentage of infection in female children (14.3%) than in male children (10.9%). The positive results by different diagnostic tools, STAT, RBPT, ELISA- IgM, ELISA-IgG and brucella genus specific PCR were 10.6%, 7.2%, 7.2%, 0.85% and 1.3% respectively. Main associated clinical symptoms were joint pain, low backache, fatigue and night sweat.

Conclusions

This hospital based study reflects a significant number of childhood brucellosis cases in Eastern zone of India, and thus emphasizes the need for further monitoring of such subjects.

Keywords

Childhood brucellosis PUO STAT RBPT ELISA PCR 

Notes

Acknowledgements

The authors hereby acknowledge the support received from all staffs of Department of Microbiology, Peerless Hospital & B. K. Roy Research Centre, Kolkata.

Contributions

All the authors were involved in the study. DD performed the study protocols, analyzed the data and drafted the manuscript. SD designed the study, critically reviewed, finalized the manuscript and will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

This study was funded by the Department of Biotechnology (DBT), Government of India (Grant No. & Date: 102/IFD/SAN/3141/2012–2013 dated September, 27 2012).

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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Devarati Dutta
    • 1
  • Anindita Sen
    • 2
  • Debkishore Gupta
    • 3
  • Prabir Kuila
    • 1
  • Debasmita Chatterjee
    • 4
  • Sugat Sanyal
    • 5
  • Satadal Das
    • 1
  1. 1.Brucella Research LaboratoryPeerless Hospital & B.K. Roy Research CentreKolkataIndia
  2. 2.Department of MicrobiologyMGM Medical CollegeKishanganjIndia
  3. 3.Department of Microbiology & Infection ControlCMRI and BM Birla Heart Research CentreKolkataIndia
  4. 4.Department of Food Technology & Biochemical EngineeringJadavpur UniversityKolkataIndia
  5. 5.Department of LaboratoryPeerless Hospital & B.K. Roy Research CentreKolkataIndia

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