Genetic and Syndromic Causes of Obesity and its Management

Review Article
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Abstract

The aim of this article is to provide an in depth review of the rare genetic and syndromic forms of childhood obesity. The authors demonstrate the complexity and inter-relationships of the leptin-melanocortin signaling pathway and its central nervous system and systemic effects. Authors highlight the clinical distinctive features of genetic/syndromic causes for childhood obesity, in particular, relative shorter height to their genetic potential, developmental challenges and in some instances, ophthalmological and retina changes. They outline specific genetic testing and treatment options available for these conditions.

Keywords

Monogenic obesity Syndromic obesity Clinical assessment Leptin-melanocortin signaling pathway 

Notes

Contributions

IHK drafted the manuscript and developed it ready for submission. IHK is the corresponding author. CR provided oversight of manuscript editing and developed the included figure and Table 1. Senior author. Dr. Catherine Pihoker, Professor of Pediatrics / University of Washington, Division of Endocrinology and Diabetes, Seattle Children’s Hospital will act as guarantor for this paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  1. 1.Division of Endocrinology and Diabetes, Department of PediatricsSeattle Children’s Hospital, University of WashingtonSeattleUSA
  2. 2.Center for Integrative Brain Research, Seattle Children’s Research InstituteSeattleUSA

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