Genetic and Syndromic Causes of Obesity and its Management
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The aim of this article is to provide an in depth review of the rare genetic and syndromic forms of childhood obesity. The authors demonstrate the complexity and inter-relationships of the leptin-melanocortin signaling pathway and its central nervous system and systemic effects. Authors highlight the clinical distinctive features of genetic/syndromic causes for childhood obesity, in particular, relative shorter height to their genetic potential, developmental challenges and in some instances, ophthalmological and retina changes. They outline specific genetic testing and treatment options available for these conditions.
KeywordsMonogenic obesity Syndromic obesity Clinical assessment Leptin-melanocortin signaling pathway
IHK drafted the manuscript and developed it ready for submission. IHK is the corresponding author. CR provided oversight of manuscript editing and developed the included figure and Table 1. Senior author. Dr. Catherine Pihoker, Professor of Pediatrics / University of Washington, Division of Endocrinology and Diabetes, Seattle Children’s Hospital will act as guarantor for this paper.
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