The Indian Journal of Pediatrics

, Volume 85, Issue 2, pp 93–101 | Cite as

Association of IL-10 Gene Polymorphism (−819C > T, −592C > A and −1082G > A) with Preterm Birth

  • Monika Pandey
  • Shally Awasthi
  • Urmila Singh
  • Abbas Ali Mahdi
Original Article



To analyze the association of IL-10 gene and its polymorphisms with preterm birth (PTB).


Five hundred and fifty nine women with term birth and 559 with preterm birth were recruited from Lucknow, India. Genetic association analysis was conducted between cases and controls. Subjects recruited as cases were women (aged between 18–40 y) with singleton delivery before 37 wk of gestation and controls were with delivery after or on 37 wk. The genotyping was performed for rs1800871, rs1800872 and rs1800896 for assessing the allelic distribution, haplotypic association and linkage disequilibrium analysis. IL-10mRNA levels were evaluated by real time quantitative polymerase chain reaction (PCR) method.


The risk of PTB was found significant in women carrying IL-10 (−1082) GA genotype [OR=1.72(1.7–2.5), p=0.006]. The haplotypic analysis of studied polymorphisms for rs1800871, rs1800872 and rs1800896 depicted the association of ATA (p=0.02) and ATC (p=0.01) haplotypes with PTB. The IL-10 mRNA levels were significantly lower in cases (p=0.05).


IL-10 marks a protective impact in the inflammatory pathway of PTB.


Cytokines Inflammation Interleukin Gene expression Haplotype Polymorphisms Preterm birth 



MP, SA: Conception or design of the experimental work and data collection; MP, SA, US, AAM: Acquisition, analysis, and interpretation of data. SA will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding

The study was financially supported by Indian Council of Medical Research (ICMR) 5/7/513/11-RHN.


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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Monika Pandey
    • 1
  • Shally Awasthi
    • 1
  • Urmila Singh
    • 2
  • Abbas Ali Mahdi
    • 3
  1. 1.Department of PediatricsKing George’s Medical UniversityLucknowIndia
  2. 2.Department of Obstetrics and GynecologyKing George’s Medical UniversityLucknowIndia
  3. 3.Department of BiochemistryKing George’s Medical UniversityLucknowIndia

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