Serum Zinc Levels as a Predictor of Severity of Acute Diarrhea
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To determine relationship between serum zinc levels and severity of diarrhea as determined by hydration status, duration of diarrhea and requirement for hospitalization. Also, to compare serum zinc levels in relation to rotavirus status.
A prospective observational study which included 254 children aged 6 mo to 5 y with diarrhea was conducted.
Serum zinc levels could be estimated in 198 children. Median (IQR) serum zinc levels of study population were 73.5 (59.11–92.86)μg/dl. Median (IQR) of serum zinc levels in children with dehydration and without dehydration were 69.64 (54.57–81.62) and 82.86 (64.1–103.48) μg/dl respectively (p < 0.001). Median (IQR) of serum zinc levels in hospitalised and non-hospitalished children were 63.28 (51.81–85.37) and 74.86 (61.75–95.78) μg/dl, respectively (p 0.013). Median (IQR) of total duration of diarrhea was 4.8 (3.5–6.0) d and it did not correlate with serum zinc levels. Median (IQR) of serum zinc levels in children, with rotavirus diarrhea was 66.8 (49.7–82.48) and non-rotavirus diarrhea was 80.0 (62.42–100.12) μg/dl (p < 0.001).
Children with dehydration and those with rotavirus diarrhea tend to have significantly lower serum zinc levels. Hospitalized children also have lower serum zinc levels than non-hospitalized children. Duration of diarrhea does not relate with serum zinc levels.
KeywordsDehydration Diarrhea Duration Rotavirus Zinc levels
AU and DS planned and supervised the study. AA, NKG, and VJ collected the data, reviewed the literature and prepared the manuscript. RKS provided biochemical results and critical inputs into the final version of manuscript. AA and DS analyzed the data and critically revised the manuscript for important intellectual content. AU will act as guarantor of study.
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- 5.The Treatment of Diarrhea. A Manual for Physicians and Other Senior Health Workers. Geneva: World Health Organization; 2005.Google Scholar
- 8.Chaudhary S, Verma M, Dhawan V, et al. Plasma vitamin A, zinc and selenium concentrations in children with acute and persistent diarrhoea. J Diarrhoeal Dis Res. 1996;14:190–3.Google Scholar
- 10.Ji-ling X, Xiao-tai H. Serum zinc level of rotaviral enteritis in children and the significance of zinc treatment. J Pediatr Pharm. 2010;1. http://en.cnki.com.cn/Article_en/CJFDTOTALEKYX201001010.htm.