Asthma, GERD and Obesity: Triangle of Inflammation
There is increasing prevalence of both asthma and obesity in children globally in recent years. Various epidemiological studies link obesity as a risk factor for asthma and suggest a possible causal association. Obesity asthma phenotype is considered as distinct in view of greater severity and poor asthma control. Various mechanisms underlying this phenotype have been suggested including mechanical effects of obesity and systemic inflammation, but still the exact mechanism is unclear. Also, the comorbidities like gastroesophageal reflux disease (GERD) and sleep disordered breathing (SDB) lead to inflammation in airways and contribute to asthma obesity association. A better understanding of mechanisms by which obesity and GERD lead to inflammation in airways and increase the risk of asthma may provide insight towards targeted treatment approach of these patients.
KeywordsAsthma Gastroesophageal reflux Obesity Sleep disordered breathing Inflammation
SG: Literature search, analysis and manuscript writing, RL: Manuscript writing and analysis, SKK: Manuscript writing and will act as guarantor for the manuscript.
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- 1.Global Asthma Network. The global asthma report 2014. Auckland, New Zealand. Available at: www.globalasthmanetwork.org. Accessed on 27th May 2017.
- 3.Novosad S, Khan S, Wolfe B, Khan A. Role of obesity in asthma control, the obesity-asthma phenotype. J Allergy (Cairo). 2013;2013:538642.Google Scholar
- 18.Coffey MJ, Torretti B, Mancuso P. Adipokines and cysteinyl leukotrienes in the pathogenesis of asthma. J Allergy (Cairo). 2015;2015:157919.Google Scholar
- 19.Sood A, Shore SA. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies. J Allergy (Cairo). 2013;2013:785835.Google Scholar
- 24.Vijayakanthi N, Greally JM, Rastogi D. Pediatric obesity-related asthma: the role of metabolic dysregulation. Pediatrics. 2016;137 https://doi.org/10.1542/peds.2015-0812. Epub 2016 Apr 8
- 38.Littner MR, Leung FW, Ballard ED. Huang B, Samra NK; Lansoprazole asthma study group. Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms. Chest. 2005;128:1128–35.CrossRefPubMedGoogle Scholar