Bordetella Pertussis Infection in Hospitalized Infants with Acute Bronchiolitis

  • Şule Gökçe
  • Zafer Kurugöl
  • S. Şöhret Aydemir
  • Candan Çiçek
  • Aslı Aslan
  • Güldane Koturoğlu
Original Article

Abstract

Objective

To assess the frequency of B. pertussis infection among young infants hospitalized with acute bronchiolitis and to determine whether B. pertussis infection affects the clinical course of acute bronchiolitis.

Methods

A total of 172 infants <6 months of age hospitalized with acute bronchiolitis were tested for B. pertussis and respiratory viruses with real-time PCR. Cases were divided into 2 groups according to B. pertussis positive or negative. Clinical parameters, clinical severity scores and laboratory characteristics of the pertussis-positive and pertussis-negative cases were compared.

Results

Bordetella pertussis infection was detected in 44 (25.6%) of the 172 infants hospitalized for acute bronchiolitis, and as co-infection with respiratory viral agents in 27 (61.4%) infants. Of the 44 pertussis-positive infants, only 17 (38.6%) experienced a paroxysmal cough, 13 (29.5%) had whooping and 15 (34.1%) had post-tussive vomiting. There was no significant difference between pertussis-positive and pertussis-negative infants according to Wang clinical score at admission (4.9 ± 1.5 vs. 5.2 ± 2.5; p = 0.689). The overall disease severity score was also similar between the two groups (6.5 ± 1.4 vs. 6.9 ± 1.6; p = 0.095).

Conclusions

Bordetella pertussis infection is common in young infants hospitalized for acute bronchiolitis, mostly as co-infection with respiratory viruses. The clinical features of pertussis in the infants are not characteristic. Viral bronchiolitis and pertussis cases could not be differentiated by clinical findings. Co-infection with pertussis did not affect the clinical outcome in infants hospitalized with acute bronchiolitis.

Keywords

Bordetella pertussis Infant Acute bronchiolitis Respiratory viruses Disease severity score 

Notes

Acknowledgments

The authors would like to thank the study staff at the Microbiology Laboratory for conducting the study, and the infants and their families for participating in the study.

Contributions

All the authors were involved in screening and management of cases. SG analyzed and drafted the manuscript. ZK and SSA critically reviewed and finalized the manuscript. ZK will act as guarantor for this paper.

Compliance with Ethical Standards

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or National Research Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The local ethics committee approved this study (reference number B.30.2.EGE.0.20.05.00/OY/1153/457).

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Şule Gökçe
    • 1
  • Zafer Kurugöl
    • 2
  • S. Şöhret Aydemir
    • 3
  • Candan Çiçek
    • 3
  • Aslı Aslan
    • 1
  • Güldane Koturoğlu
    • 1
  1. 1.Department of Pediatrics, General Pediatrics UnitEge UniversityIzmirTurkey
  2. 2.Division of Pediatric Infection, Department of PediatricsEge UniversityIzmirTurkey
  3. 3.Department of MicrobiologyEge UniversityIzmirTurkey

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