The Indian Journal of Pediatrics

, Volume 85, Issue 1, pp 10–14 | Cite as

Platelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness

  • Pragati Purbiya
  • Zainab Mohammedi Golwala
  • Ayush Manchanda
  • V. Sreenivas
  • Jacob M. Puliyel
Original Article
  • 57 Downloads

Abstract

Objective

To prospectively validate association between the ratio of platelet distribution width (PDW)/platelet count (PCT) and pediatric intensive care unit (PICU) mortality.

Methods

The study was done in the pediatric intensive care unit (PICU). Platelet indices in the first sample taken after admission were used. In this case control analysis, cases were the patients who died in PICU and the survivors served as controls. Consecutive 209 eligible patients over a period of 15 mo from January 2014 through March 2015 were included. Exposure was PDW/PC above 0.07. Of them 174 survived and 35 died.

Results

The mean PDW for survivors was 16.77 (±0.92) and for those who died it was 17.33 (±1.03) (p 0.0015). Mean platelet count (PC) for survivors was 3,46,000 (±1,64,700) and for those who died it was 1,75,800 (±1,61,500) (p < 0.001). PDW/PC for survivors was 0.12 (±0.46) and for those who died it was 0.336 (±0.53) (p 0.0014). Using the cut-off of 0.07 for PDW/PC described by Golwala et al., 77.14% above the cut-off died, compared to 22.85% below that cut-off. The odds ratio (OR) for death was 10.6 (95% CI: 4.48 to 25.12). The area under the receiver operating curve (ROC) curve for PDW/PC ratio was 0.81.

Conclusions

The ratio of PDW/PC, higher than 0.07 in the first sample after admission can be considered as an independent predictor of mortality with sensitivity and specificity of 77.1% and 77.5%, respectively. It may be a useful component for inclusion in composite scores for predicting mortality.

Keywords

Platelet indices Critical care in pediatrics Predicting mortality in hospital 

Notes

Acknowledgements

All the co-authors and hospital staff helped in unified way to make this research work possible. Dr. Purbiya is especially grateful to the head of department, Dr. Jacob M. Puliyel, for providing valuable guidance and support at each step right from conceptualizing the hypothesis to submission of manuscript.

Contributions

PP: Collected and compiled the data for the study and drafted the manuscript; JMP: Conceptualized and designed the study and finalized the manuscript; ZMG and AM: Provided intellectual inputs from protocol stage and helped in drafting paper; VS: Did the sample size calculation and statistical analysis. All the authors performed critical review. JMP will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

None.

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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Pragati Purbiya
    • 1
    • 2
  • Zainab Mohammedi Golwala
    • 1
  • Ayush Manchanda
    • 1
  • V. Sreenivas
    • 3
  • Jacob M. Puliyel
    • 1
  1. 1.Department of PediatricsSt Stephens HospitalDelhiIndia
  2. 2.IndoreIndia
  3. 3.Department of BiostatisticsAll India Institute of Medical SciencesNew DelhiIndia

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