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The Indian Journal of Pediatrics

, Volume 85, Issue 1, pp 77–78 | Cite as

Prevalence of Parvovirus B19V in Hematological Malignancies and Chronic Anemia

  • Amita Jain
  • Parul Jain
  • Shantanu Prakash
  • Danish N. Khan
  • Archana Kumar
  • Ravi Kant
Scientific Letter

To the Editor: The present study was planned to estimate the prevalence of human Parvovirus B19 (B19V) infection in children suffering with hematological malignancies or chronic anemia. Such hospitalized children (<15 y) were enrolled consecutively from 2011 through 2014. King George’s Medical University’s institutional ethical clearance was obtained (no.52 E.C.M.IIA/P6). Anti B19V IgG and IgM antibodies (ELISA kits by NovaTech Immunodiagnostica, Dietzenbach, Germany) and B19V DNA (by real time PCR [1]) were estimated in serum samples of enrolled patients. Relevant laboratory parameters were noted from hospital records of cases. Statistical analysis was done using GraphPad Prism Version 5.

Total 379 children were enrolled [Leukemia: 270 cases, chronic unexplained anemia: 109 cases; boys: 264(69.7%), girls: 115(30.3%)]. Mean age ± SD was 6.89 ± 4.17. A high prevalence (70.2%) of B19V infection (presence of any of the three markers) was seen in the study population. No statistically...

Notes

Compliance with Ethical Standards

Conflict of Interest

None.

Source of Funding

We acknowledge financial support from Indian Council of Medical Research, New Delhi, India, for providing funding (grant no. 5/8/7/17/2010-ECD-1).

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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Amita Jain
    • 1
  • Parul Jain
    • 1
  • Shantanu Prakash
    • 1
  • Danish N. Khan
    • 1
  • Archana Kumar
    • 2
  • Ravi Kant
    • 3
  1. 1.Department of MicrobiologyKing George’s Medical UniversityLucknowIndia
  2. 2.Department of PediatricsKing George’s Medical UniversityLucknowIndia
  3. 3.King George’s Medical UniversityLucknowIndia

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