Power Color Doppler and Spectral Doppler Ultrasonography to Evaluate Response to Intra-articular Steroid Injection in Knee Joints in Juvenile Idiopathic Arthritis
- 114 Downloads
To evaluate the role of ultrasonographic indices (Color Fraction and Resistive Index) in assessing the effect of intra-articular steroid (IAS) injection on synovial inflammation in knee joints of Juvenile Idiopathic Arthritis (JIA) patients and to determine the correlation between these ultrasonographic indices and clinical and laboratory parameters in JIA patients after IAS.
Twenty seven patients of JIA and equal number of age and sex matched healthy controls were enrolled. Thirty six knee joints were injected with IAS. Duration of morning stiffness, swelling score, tenderness score, range of motion, visual analogue scale for pain, Physician global assessment of disease activity, Patient/Parent assessment of general well being, Juvenile Arthritis Disease Activity Score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), synovial thickness, synovial effusion, Color fraction (CF) and Resistive index (RI) were measured at base line and at one and two months of follow-up.
At baseline, a significant difference was found in ESR, CRP, CF and RI values between cases and controls. A significant decrease in various clinical, core set variables and ultrasonographic parameters was observed at each follow-up. Synovial thickness, synovial effusion and CF decreased by 51.78%, 64.67% and 49.35% respectively and range of motion and RI increased by 166% and 31.94% respectively at second follow-up. Both CF and RI showed a significant correlation with active joint count. Both CF and RI had a high inter and intra-class correlation.
Power Color Doppler and Spectral Doppler ultrasonographic indices (CF and RI) may have a role in assessment of the response to IAS injection of inflamed knee joints.
KeywordsJuvenile idiopathic arthritis Intra-articular steroids Ultrasonography
TB collected the data, analysed and wrote the manuscript. He shall be the first author. He also underwent training in ultrasonography in muskuloskeletal disorders (MSK) for 3 weeks and then did USG under supervision and later took part in reliability study; AC provided intellectual contribution towards manuscript writing; TPV conceptualised the study and contributed to analysis and drafting the manuscript and giving the final shape. He shall act as guarantor of the paper; NS collected the data, analysed and edited the manuscript; VD contributed to manuscript writing and editing.
Compliance with Ethical Standards
Conflict of Interest
Source of Funding
- 4.Cassidy JT, Petty RE. Chronic arthritis in children. In: Cassidy JT, Petty RE, Laxer RM, Lindley CB, editors. Chapter 13 in Text Book of Pediatric Rheumatology. 6th ed. Philadelphia: Elsevier Saunder; 2011. p. 211–34.Google Scholar
- 6.Consolaro A, Ruperto N, Bazso A, et al; Paediatric Rheumatology International Trials Organisation. Development and validation of a composite disease activity score for juvenile idiopathic arthritis. Arthritis Rheum. 2009;61:658–66.Google Scholar
- 17.Laurell L, Court-Payen M, Nielsen S, Zak M, Fasth A. Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the wrist region. A descriptive interventional study. Pediatr Rheumatol Online J. 2012;10:11.Google Scholar