The Indian Journal of Pediatrics

, Volume 84, Issue 11, pp 822–825 | Cite as

Chronic Kidney Disease (CKD): An Observational Study of Etiology, Severity and Burden of Comorbidities

  • Nivedita Kamath
  • Arpana Aprameya Iyengar
Original Article



To study the etiology and burden of comorbidities across stages of chronic kidney disease (CKD).


Children, 2–16 y of age with CKD Stages II- IV were recruited over 12 mo. The etiology, clinical presentation and severity of complications were studied.


Among 78 children [Stage II (n = 21), Stage III (n = 26), Stage IV (n = 31)], congenital anomalies of the kidney and urinary tract (CAKUT) was the commonest etiology and 28 were newly diagnosed in Stage III /IV. High prevalence of comorbidities was observed with growth retardation (65%), hypertension (59%), hyperphosphatemia (32%), vitamin D deficiency (92%), dyslipidemia (64%), left ventricular hypertrophy (45%) and hyperparathyroidism (56%). While most comorbidities correlated with the estimated glomerular filtration rate and severity of CKD, hypertension, vitamin D deficiency and cardiovascular morbidity were prevalent even in early stages.


CAKUT was the commonest cause of CKD. Late detection and high prevalence of comorbidities even in early stages of CKD were observed.


Chronic kidney disease Children 



NK designed the study, recruited patients, conducted the evaluation and data analysis and drafted the manuscript. AAI contributed to the concept and study design, took overall responsibility of the study, gave inputs on data interpretation and prepared the manuscript. AAI will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding

Funded by International Society of Nephrology Clinical Research Program Grant.


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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  1. 1.Department of Pediatric NephrologySt John’s Medical College HospitalBangaloreIndia

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