The Indian Journal of Pediatrics

, Volume 84, Issue 6, pp 425–429 | Cite as

Efficacy and Safety of 2% Topical Propranolol Cream for the Treatment of Proliferating Infantile Strawberry Hemangiomas

  • Yuanyuan Wang
  • Xingcun Zhang
  • Yadong Yang
  • Junbo Zhang
  • Yunchuan Yang
  • Yuangang Lu
Original Article



To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas.


A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment.


The overall response was graded Scale 1 (poor response) in 2 patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 17 patients, and Scale 4 (excellent response) in 6 patients. No significant differences were seen in treatment outcomes between female and male patients, among lesion locations/size, or in the age at the start of the treatment. No obvious AEs were reported.


2% topical propranolol cream is safe and effective for the treatment of proliferating infantile strawberry hemangiomas.


Topical propranolol Infant Strawberry hemangiomas Safety Efficacy β-adrenergic receptor blocker 



YW and XZ: Wrote the paper; YadY and JZ: Analyzed the data; YunY: Collected the pictures; YL: Reviewed the whole paper and will act as guarantor for the paper.

Compliance with Ethical Standards

Conflict of Interest


Source of Funding

The study is supported by Natural Science Foundation of China (No. 81201244).

Supplementary material

12098_2017_2303_MOESM1_ESM.docx (128 kb)
ESM 1 (DOCX 128 kb)


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Copyright information

© Dr. K C Chaudhuri Foundation 2017

Authors and Affiliations

  • Yuanyuan Wang
    • 1
  • Xingcun Zhang
    • 1
  • Yadong Yang
    • 1
  • Junbo Zhang
    • 1
  • Yunchuan Yang
    • 1
  • Yuangang Lu
    • 1
  1. 1.Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of Surgery ResearchThird Military Medical UniversityChongqingPeople’s Republic of China

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