Efficacy and Safety of 2% Topical Propranolol Cream for the Treatment of Proliferating Infantile Strawberry Hemangiomas
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To evaluate the efficacy and safety of 2% topical propranolol cream in the treatment of proliferating infantile strawberry hemangiomas.
A total of 40 infants were enrolled; 2% propranolol cream was applied three times daily. In the subsequent monthly visit, dynamic changes in tumor size, texture, and color were recorded. The adverse events (AEs) were observed. Treatment outcomes were scored on a four-point scale. All patients were followed up for 12 mo after treatment.
The overall response was graded Scale 1 (poor response) in 2 patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 17 patients, and Scale 4 (excellent response) in 6 patients. No significant differences were seen in treatment outcomes between female and male patients, among lesion locations/size, or in the age at the start of the treatment. No obvious AEs were reported.
2% topical propranolol cream is safe and effective for the treatment of proliferating infantile strawberry hemangiomas.
KeywordsTopical propranolol Infant Strawberry hemangiomas Safety Efficacy β-adrenergic receptor blocker
YW and XZ: Wrote the paper; YadY and JZ: Analyzed the data; YunY: Collected the pictures; YL: Reviewed the whole paper and will act as guarantor for the paper.
Compliance with Ethical Standards
Conflict of Interest
Source of Funding
The study is supported by Natural Science Foundation of China (No. 81201244).
- 11.Leaute-Labreze C. Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taieb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358:2649–51.Google Scholar
- 19.Bonifazi E, Colonna V, Mazzotta F, Balducci G, Laforgia N. Propranolol in rapidly growing hemangiomas. Eur J Pediatr Dermatol. 2008;18:185–92.Google Scholar