Abstract
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) is accepted as a safe and minimally invasive modality for evaluation of mediastinal pathologies in adults. There is scanty literature on the utilization and performance characteristics of Convex probe EBUS-TBNA in children. The authors herein describe two pediatric patients with mediastinal lymphadenopathy wherein the underlying diagnosis was unclear based on the clinico-radiological profile. A possibility of lymphoma was considered in one of the patients. EBUS-TBNA was performed for obtaining tissue samples from the enlarged mediastinal lymph nodes and diagnosis of tuberculosis was established in both the patients. The authors review the available literature on Pediatric EBUS TBNA. EBUS-TBNA is an exciting and promising approach towards safe and accurate evaluation of mediastinal pathologies in children. Pediatric EBUS-TBNA needs further evaluation in prospective studies.
References
Steinfort DP, Wurzel D, Irving LB, Ranganathan SC. Endobronchial ultrasound in pediatric pulmonology. Pediatr Pulmonol. 2009;44:303–8.
Gilbert CR, Chen A, Akulian JA, Lee HJ, Wahidi M, Argento AC, et al. The use of convex probe endobronchial ultrasound-guided transbronchial needle aspiration in a pediatric population: a multicenter study. Pediatr Pulmonol. 2014;49:807–15.
Wurzel DF, Steinfort DP, Massie J, Ryan MM, Irving LB, Ranganathan SC. Paralysis and a perihilar protuberance: an unusual presentation of sarcoidosis in a child. Pediatr Pulmonol. 2009;44:410–4.
Yasufuku K, Chiyo M, Sekine Y, Chhajed PN, Shibuya K, Iizasa T, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal and hilar lymph nodes. Chest. 2004;126:122–8.
Nakajima T, Yasufuku K, Yoshino I. Current status and perspective of EBUS-TBNA. Gen Thorac Cardiovasc Surg. 2013;61:390–6.
Galluccio G, Lucantoni G. Mediastinal bronchogenic cyst’s recurrence treated with EBUS-FNA with a long-term follow-up. Eur J Cardiothorac Surg. 2006;29:627–9.
Siemsen M, Andersen NE, Nielsen KG. EBUS in a 6-year-old boy with enlarged hilar lymph nodes. J Bronchology Interv Pulmonol. 2011;18:205.
Madan K, Mohan A, Ayub II, Jain D, Hadda V, Khilnani GC, et al. Initial experience with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from a tuberculosis endemic population. J Bronchology Interv Pulmonol. 2014;21:208–14.
Navani N, Molyneaux PL, Breen RA, Connell DW, Jepson A, Nankivell M, et al. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax. 2011;66:889–93.
Kennedy MP, Jimenez CA, Bruzzi JF, Mhatre AD, Lei X, Giles FJ, et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax. 2008;63:360–5.
Franco J, Monclou E. Transesophageal endobronchial ultrasound-guided fine-needle aspiration. Arch Bronconeumol. 2011;47:418–9.
Madan K, Garg P, Kabra SK, Mohan A, Guleria R. Trans-esophageal Bronchoscopic Ultrasound-guided Fine-Needle Aspiration (EUS-B-FNA) in a 3-year-old child. J Bronchology Interv Pulmonol. 2014;in press.
Acknowledgments
The authors acknowledge the valuable guidance from Prof. Pramod Garg (Department of Gastroenterology, AIIMS) towards initiating the pediatric EBUS-TBNA procedures. They also would like to thank the support staff of the bronchoscopy laboratory at the Department of Pulmonary Medicine and Sleep Disorders.
Contributions
KM, AM: Performed the EBUS-TBNA procedures and were involved in manuscript preparation; IIA: Assisting the EBUS-TBNA procedure and manuscript preparation; DJ: Cytopathology interpretation; RG: Manuscript review and suggestions; SKK: Manuscript preparation and manuscript review. SKK and RG will act as guarantor for this paper.
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Madan, K., Ayub, I.I., Mohan, A. et al. Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) in Mediastinal Lymphadenopathy. Indian J Pediatr 82, 378–380 (2015). https://doi.org/10.1007/s12098-014-1665-3
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DOI: https://doi.org/10.1007/s12098-014-1665-3