Skip to main content

Advertisement

Log in

Advances in Neurocritical Care

  • REVIEW ARTICLE
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The neurologically injured child, whether from trauma or other causes, is a common admission into any Pediatric critical care unit. Whatever the cause, the risk for death and life long disability remains very high. Unlike the adult population, neurological diseases in children are diverse and arise from a variety of factors that vary greatly in age and presentation. Nervous system dysfunction is often a complication of critical illness and interventions. While neurointensive care units may be ideal for the at-risk child, in mixed units, 40 % of admissions may be neurological or have neurological complications. Improved quality of care and the application of protocols and bundles, appear to have contributed significantly to improved outcomes. Since we are constantly facing an uphill task of dealing with deterioration while trying to preserve function, detection of early shifts of any nature would be deemed helpful. The intensivist must focus not only on saving life but also on preventing disability with full awareness that responsibility does not end with discharge from the pediatric intensive care unit (PICU). Outcome audits should include not only deaths and discharge from PICU but also one year mortality and even degree of disability at the end of one year from discharge.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Markandaya M, Thomas KP, Jahromi B, Koenig M, Lockwood AH, Nyquist PA, et al. The role of neurocritical care: a brief report on the survey results of neurosciences and critical care specialists. Neurocrit Care. 2012;16:72–81.

    Article  PubMed  Google Scholar 

  2. Kochanek PM, Carney N, Adelson PD, Bell MJ, Bratton S, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents—second edition. Pediatr Crit Care Med. 2012;13:S1–82.

    Article  PubMed  Google Scholar 

  3. Shetty R, Singhi S, Singhi P, Jayshree M. Cerebral perfusion pressure–targeted approach in children with central nervous system infections and raised intracranial pressure: is it feasible? J Child Neurol. 2008;23:192–8.

    Article  PubMed  Google Scholar 

  4. Hutchison JS, Frendova H, Lo TY. Guerguerian AM; Hypothermia Pediatric Head Injury Trial Investigators; Canadian Critical Care Trials Group. Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial. Dev Neurosci. 2010;32:406–12.

  5. Maas AIR, Murray GD, Roozenbeek B, Lingsma HF, Butcher I, McHugh GS, et al. International Mission on Prognosis Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Study Group. Advancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research. Lancet Neurol. 2013;12:1200–30.

  6. Battison C, Andrews P, Graham C, Petty T. Randomized, controlled trial on the effect of a 20% Mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med. 2005;33:196–202. discussion 257–8.

    Article  CAS  PubMed  Google Scholar 

  7. Lewandowski-Belfer JJ, Patel AV, Darracott RM, Jackson DA, Nordeen JD, Freeman WD. Safety and efficacy of repeated doses of 14.6 or 23.4 % hypertonic saline for refractory intracranial hypertension. Neurocrit Care. 2014;20:436–42.

    Article  CAS  PubMed  Google Scholar 

  8. Gonda DD, Meltzer HS, Crawford JR, Hilfiker ML, Shellington DK, Peterson BM, et al. Complications associated with prolonged hypertonic saline therapy in children with elevated intracranial pressure. Pediatr Crit Care Med. 2013;14:601–20.

    Article  Google Scholar 

  9. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al; Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008;358:2447–5.

  10. Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, et al; Paediatric Traumatic Brain Injury Consortium. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial. Lancet Neurol. 2013;12:546–53.

    Article  PubMed  Google Scholar 

  11. Bourdages M, Bigras JL, Farrell CA, Hutchison JS. Lacroix J; Canadian Critical Care Trials Group. Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy. Pediatr Crit Care Med. 2010;11:408–11.

  12. Hutchison JS, Guerguerian AM. Risk of death with therapeutic hypothermia versus normothermia in children with severe traumatic brain injury. Lancet Neurol. 2013;12:527–9.

    Article  PubMed  Google Scholar 

  13. Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand Suppl. 1960;36:1–193.

    CAS  PubMed  Google Scholar 

  14. Lundberg N, Troupp H, Lorin H. Continuous recording of the ventricular-fluid pressure in patients with severe acute traumatic brain injury a preliminary report. J Neurosurg. 1965;22:581–90.

    Article  CAS  PubMed  Google Scholar 

  15. Luerssen TG. Intracranial pressure: current status in monitoring and management. Semin Pediatr Neurol. 1997;4:146–55.

    Article  CAS  PubMed  Google Scholar 

  16. Marshall RS. The functional relevance of cerebral hemodynamics: why blood flow matters to the injured and recovering brain. Curr Opin Neurol. 2004;17:705–9.

    Article  PubMed  Google Scholar 

  17. Cormio M, Valadka AB, Robertson CS. Elevated jugular venous oxygen saturation after severe head injury. J Neurosurg. 1999;90:9–15.

    Article  CAS  PubMed  Google Scholar 

  18. Figaji AA, Kent SJ. Brain tissue oxygenation in children diagnosed with brain death. Neurocrit Care. 2010;12:56–61.

    Article  CAS  PubMed  Google Scholar 

  19. Figaji AA, Zwane E, Fieggen AG, Siesjo P, Peter JC. Transcranial Doppler pulsatility index is not a reliable indicator of intracranial pressure in children with severe traumatic brain injury. Surg Neurol. 2009;72:389–94.

    Article  PubMed  Google Scholar 

  20. Udomphorn Y, Armstead WM, Vavilala MS. Cerebral blood flow and autoregulation after pediatric traumatic brain injury. Pediatr Neurol. 2008;38:225–34.

    Article  PubMed Central  PubMed  Google Scholar 

  21. ter Horst HJ, Sommer C, Bergman KA, Fock JM, van Weerden TW, Bos AF. Prognostic significance of amplitude-integrated EEG during the first 72 h after birth in severely asphyxiated neonates. Pediatr Res. 2004;55:1026–33.

    Article  PubMed  Google Scholar 

  22. Thoresen M, Hellström-Westas L, Liu X, de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics. 2010;126:e131–9.

    Article  PubMed  Google Scholar 

  23. Toet MC, Hellström-Westas L, Groenendaal F, Eken P, de Vries LS. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 1999;81:F19–23.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Toet MC, van der Meij W, de Vries LS, Uiterwaal CS, van Huffelen KC. Comparison between simultaneously recorded amplitude integrated electroencephalogram (cerebral function monitor) and standard electroencephalogram in neonates. Pediatrics. 2002;109:772–9.

    Article  PubMed  Google Scholar 

  25. al Naqeeb N, Edwards AD, Cowan FM, Azzopardi D. Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography. Pediatrics. 1999;103:1263–71.

    Article  PubMed  Google Scholar 

  26. Abend NS, Wusthoff CJ, Goldberg EM. Dlugos DJ Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol. 2013;12:1170–9. doi:10.1016/S1474-4422(13)70246-1.

    Article  PubMed  Google Scholar 

  27. Kurtz P, Gaspard N, Wahl AS, Bauer RM, Hirsch LJ, Wunsch H, et al. Continuous electroencephalography in a surgical intensive care unit. Intensive Care Med. Nov 2013 1–7.

  28. Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T, et al; Neurocritical Care Society Status Epilepticus Guideline Writing Committee. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17:3–23.

    Article  PubMed  Google Scholar 

  29. Suh DY, Davis PC, Hopkins KL, Fajman NN, Mapstone TB. Nonaccidental pediatric head injury: diffusion weighted imaging findings. Neurosurgery. 2001;49:2309–20.

    Google Scholar 

Download references

Conflict of Interest

None.

Source of Funding

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Soonu Udani.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Udani, S. Advances in Neurocritical Care. Indian J Pediatr 82, 272–276 (2015). https://doi.org/10.1007/s12098-014-1586-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-014-1586-1

Keywords

Navigation