The Indian Journal of Pediatrics

, Volume 82, Issue 3, pp 225–229 | Cite as

Bone Mineral Density in Ambulatory Children with Epilepsy

  • Omid Yaghini
  • Seyed Hasan TonekaboniEmail author
  • Seyed Mohammad Amir Shahkarami
  • Farzad Ahmad Abadi
  • Fakhredin Shariat
  • Fatemeh Abdollah Gorji
Original Article



To elucidate the effects of antiepileptic drugs (AEDs) on bone health status of ambulatory epileptic children.


A total of 120 epileptic children aged 2–15 y were enrolled in three groups. The first group was on therapy with carbamazepine, phenobarbital or primidone. The second was treated with valproic acid and the third group was untreated. Serum calcium, phosphorous, total alkaline phosphatase, and parathyroid hormone levels were compared between groups. Bone mineral density tests were also performed at four sites of the lumbar spine and three sites of femoral neck and results were compared between the groups.


Of all enrolled subjects, 67 patients (55.8 %) were vitamin D deficient. The three groups were not significantly different in terms of vitamin D, calcium, phosphorus, total alkaline phosphatase, and parathyroid hormone levels. While patients in first group had lower Z-score of femoral neck and lumbar spine compared to those on valproic acid, these values were also significantly different than that of the third group.


It can be concluded that both enzyme-inducing AEDs and non enzyme-inducing AEDs decrease bone mineral density (BMD). Also alkaline phosphatase (ALP) is affected in ambulatory epileptic children on enzyme-inducing AEDs. Nevertheless, valproic acid (a non-enzyme-inducing agent) does not have the mentioned side effects.


Antiepileptic drugs Bone mineral density Vitamin D Epilepsy Children 


Conflict of Interest


Source of Funding

Shahid Beheshti University of Medical Sciences.


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Copyright information

© Dr. K C Chaudhuri Foundation 2014

Authors and Affiliations

  • Omid Yaghini
    • 1
    • 4
  • Seyed Hasan Tonekaboni
    • 2
    • 8
    Email author
  • Seyed Mohammad Amir Shahkarami
    • 3
    • 4
  • Farzad Ahmad Abadi
    • 5
  • Fakhredin Shariat
    • 6
  • Fatemeh Abdollah Gorji
    • 7
  1. 1.Pediatric Neurology Unit, Department of PediatricsIsfahan University of Medical SciencesIsfahanIran
  2. 2.Pediatric Neurology Unit, Department of PediatricsShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Department of PediatricsIsfahan University of Medical SciencesIsfahanIran
  4. 4.Child Growth and Development Research CenterIsfahan University of Medical SciencesIsfahanIran
  5. 5.Pediatric Neurology Unit, Department of PediatricsArdabil University of Medical SciencesArdabilIran
  6. 6.Pediatric Neurology Unit, Department of PediatricsArak University of Medical SciencesArakIran
  7. 7.Department of StatisticsShahid Beheshti University of Medical SciencesTehranIran
  8. 8.Department of Pediatric NeurologyMofid Children HospitalTehranIran

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