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Effect of Inhaled Magnesium Sulfate on Bronchial Hyperresponsiveness

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Abstract

Objectives

To determine the response of nebulized magnesium sulfate on the lung function of children with bronchial hyperresponsiveness.

Methods

Eighty-four children with asthma were divided into three groups randomly: magnesium sulfate (M), albuterol (A), and a combination of magnesium sulfate and albuterol (M + A). All patients were nebulized with acetylcholine, and then treated as designed. Lung function was compared between the three groups.

Results

Forced expiratory volume in first second (FEV1) significantly improved in all the three groups but it was better in (A) and (M + A) compared to (M) at 10 min and 20 min [10 min: 1.26 L ± 0.53 (A) vs. 1.10 L ± 0.27 (M), 1.35 L ± 0.59 (M + A) vs. 1.10 L ± 0.27 (M), p < 0.05; 20 min: 1.32 L ± 0.61 (A) vs. 1.17 L ± 0.30 (M), 1.42 L ± 0.59 (M + A) vs. 1.17 L ± 0.30 (M), p < 0.05]. Variation of FEV1, as absolute value at 10 min or 20 min over post-Ach FEV1 was significantly different in (A) or (M + A) compared to (M).

Conclusions

Nebulized albuterol and magnesium sulfate + albuterol can more effectively improve FEV1 in children with bronchial hyperresponsiveness than nebulized magnesium sulfate at 10 min and 20 min after inhalation. It is further suggested that addition of magnesium sulfate to albuterol does not result in additional benefit.

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Acknowledgments

The authors would like to thank Dr. Hongmei Nie and Dr. Bin Pen for assistance of statistic analysis.

Contributions

HW and CG: Contributed equally to this study; HW: Involved in the data analyses and prepared the manuscript; Lijuan Yin, Li Yan, XY: Recruited the patients; SL and TS: Performed lung function tests; JD: Designed, supervised the study and will act as guarantor for this paper. All the authors have read and approved the final manuscript.

Conflict of Interest

None.

Source of Funding

This study is funded by Chongqing Science & Technology Commission (cstc2012jjA0115).

Author information

Authors and Affiliations

  1. Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China

    Hui Wang

  2. Center of Respiratory Disorders, Children’s Hospital, Chongqing Medical University, No.136, 2nd Road of Zhongshan, Yuzhong District, Chongqing, 400014, China

    Hui Wang, Lijuan Yin, Li Yan, Xiaoping Yuan & Jihong Dai

  3. Maternal and Child-Care Hospital of Zunyi, Zunyi City, Guizhou Province, China

    Yi Xiong

  4. Laboratory of Pulmonary Function Test, Children’s Hospital, Chongqing Medical University, Chongqing, China

    Caihui Gong, Sha Liu & Tiantian Shi

Authors
  1. Hui Wang
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  2. Yi Xiong
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  3. Caihui Gong
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  4. Lijuan Yin
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  5. Li Yan
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  6. Xiaoping Yuan
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  7. Sha Liu
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  8. Tiantian Shi
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  9. Jihong Dai
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Corresponding author

Correspondence to Jihong Dai.

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Wang, H., Xiong, Y., Gong, C. et al. Effect of Inhaled Magnesium Sulfate on Bronchial Hyperresponsiveness. Indian J Pediatr 82, 321–327 (2015). https://doi.org/10.1007/s12098-014-1476-6

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  • DOI: https://doi.org/10.1007/s12098-014-1476-6

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