Abstract
Objective
To evaluate the role of Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) in differentiating interleukin 11 induced fever with C-reactive protein elevation from early bacterial infection.
Methods
A total of 74 patients were enroled in this retrospective study. Serum Th1/Th2 cytokines were determined using cytometric bead array (CBA) techniques. Whenever the patients had febrile disease or elevated CRP, systemic inflammatory signs, procalcitonin (PCT), blood culture and X-ray examination were done. The patients were assigned into infected and non-infected groups based on the clinical and laboratory findings.
Results
The CRP levels in both the groups were significantly increased, but no statistically significant difference was found (P = 0.574). IL-6 levels of the infected group were significantly elevated with simultaneously elevated IL-10 levels in a proportion of the patients. IL-6 levels of non-infected patients were normal. IL-6 and IL-10 levels of infected patients were significantly higher than those of non-infected patients (P = 0.005, 0.015, respectively).
Conclusions
For the patients treated with recombinant human interleukin 11 (rhIL-11), IL-6 and IL-10 measurements can be a useful adjuvant tool for the differentiation of rhIL-11 induced fever with C-reactive protein elevation from early bacterial infection.
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Contribution
Dr. Yongmin Tang will act as guarantor for this paper.
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None.
Role of Funding Source
This work was supported in part by Grants from the Science Technology Department of Zhejiang Province (Qianjiang project: 2011R10037), the National Natural Science Fundation of China, No. 81170502, and Zhejiang Provincial Natural Science Fundation of China, No. LZ12H08001.
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Liang, J., Lei, Z., Xu, X. et al. Role of Interleukin-6 in Differentiating Interleukin-11 Induced Fever and Early Bacterial Infection. Indian J Pediatr 81, 871–875 (2014). https://doi.org/10.1007/s12098-014-1361-3
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DOI: https://doi.org/10.1007/s12098-014-1361-3