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B Cell Suppression in Newborn Following Treatment of Pregnant Diffuse Large B-cell Lymphoma Patient with Rituximab Containing Regimen

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Abstract

Non-Hodgkin lymphoma associated with pregnancy is rare. Rituximab based chemotherapy is now considered the standard of care and considered safe for the treatment of diffuse large B-cell lymphoma (DLBCL) during pregnancy but little is known about its safety profile on the fetus. A 32 y primigravida was diagnosed as DLBCL at 20 wk of gestation. She received rituximab containing chemotherapy with successful pregnancy outcome. Though the baby was absolutely healthy, B-cell was totally absent in the cord blood.

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References

  1. Lishner M, Zemlickis D, Sutcliffe SB, Koren G. Non-Hodgkin’s lymphoma and pregnancy. Leuk Lymphoma. 1994;14:411–3.

    Article  PubMed  CAS  Google Scholar 

  2. Stiehm ER, Fudenberg HH. Serum levels of immune globulins in health and disease: A survey. Pediatrics. 1966;37:715–27.

    Google Scholar 

  3. Chakravarty EF, Murray ER, Kelman A, Farmer P. Pregnancy outcomes following maternal exposure to rituximab. Blood. 2011;117:1499–506.

    Article  PubMed  CAS  Google Scholar 

  4. Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010;362:529–35.

    Article  PubMed  CAS  Google Scholar 

  5. Saji F, Samejima Y, Kamiura S, Koyama M. Dynamics of immunoglobulins at the feto maternal interface. Rev Reprod. 1999;4:81–9.

    Article  PubMed  CAS  Google Scholar 

  6. Decker M, Rothermundt C, Holländer G, Tichelli A, Rochiltz C. Rituximab plus CHOP for treatment of diffuse large B-cell lymphoma during second trimester of pregnancy. Lancet Oncol. 2006;7:693–4.

    Article  PubMed  Google Scholar 

  7. Mouquet H, Musette P, Gougeon ML, Jacquot S, Lemercier B, Lim A, et al. B-cell depletion immunotherapy in pemphigus: Effects on cellular and humoral immune responses. J Invest Dermatol. 2008;128:2859–69.

    Article  PubMed  CAS  Google Scholar 

  8. Klink DT, van Elburg RM, Schreurs MWJ, Van Well GT. Rituximab administration in third trimester of pregnancy suppresses neonatal B-cell development. Clin Dev Immunol. 2008;2008:271–363.

    Article  Google Scholar 

  9. Gupta N, Sharma S, Seth T, Mishra P, Mahapatra M, Kumar S, et al. Rituximab in steroid refractory autoimmune hemolytic anemia. Indian J Pediatr. 2012;79:803–5.

    Article  PubMed  Google Scholar 

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Contribution

Dr. Malay Kumar Ghosh will act as guarantor for this paper.

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Authors and Affiliations

  1. Department of Hematology, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata, 700014, India

    Prakas Kumar Mandal, Tuphan Kanti Dolai, Basab Bagchi, Malay Kumar Ghosh & Maitreyee Bhattacharyya

  2. Department of Gynecology, Midnapore Medical College and Hospital, Midnapore, West Bengal, India

    Sudipta Bose

Authors
  1. Prakas Kumar Mandal
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  2. Tuphan Kanti Dolai
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  3. Basab Bagchi
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  4. Malay Kumar Ghosh
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  5. Sudipta Bose
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  6. Maitreyee Bhattacharyya
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Correspondence to Tuphan Kanti Dolai.

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Mandal, P.K., Dolai, T.K., Bagchi, B. et al. B Cell Suppression in Newborn Following Treatment of Pregnant Diffuse Large B-cell Lymphoma Patient with Rituximab Containing Regimen. Indian J Pediatr 81, 1092–1094 (2014). https://doi.org/10.1007/s12098-013-1336-9

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  • DOI: https://doi.org/10.1007/s12098-013-1336-9

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