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Spirometric Evaluation in Juvenile Idiopathic Arthritis: Data from Eastern India

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Abstract

Objective

To evaluate lung function in juvenile idiopathic arthritis (JIA) patients.

Methods

This was a case control study carried out at Institute of Post-Graduate Medical Education & Research, Kolkata, involving JIA patients between 5 and 12 y. They were diagnosed and classified on the basis of International League of Associations for Rheumatology (ILAR) criteria and compared with same number of age, sex, height and weight matched controls. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, forced expiratory flow between 25 and 75 % of vital capacity (FEF25–75%) and peak expiratory flow rate (PEFR) of cases were compared to those of matched controls.

Results

Among 36 JIA patients initially recruited, 9 were excluded. Of the remaining 27 patients, male: female ratio was 17:10. Mean age, height and weight of JIA patients were 9.15 y, 124.67 cm and 23.78 kg respectively. Six patients had oligoarthritis, 3 had rheumatoid factor positive (RF+) polyarthritis, 10 had rheumatoid factor negative (RF-) polyarthritis and 8 had systemic JIA. Eleven patients had active disease and 15 patients required methotrexate. None had respiratory symptoms. Mean duration of the disease was 2.96 y. Mean FVC and FEV1 were significantly less in JIA patients compared to controls (p value = 0.0003 and 0.0007, respectively). FEV1/FVC in both the groups was similar (p value = 0.96). Mean Z scores for FVC and FEV1 were significantly higher in JIA patients (p value = 0.0064 and 0.0030, respectively).

Conclusion

Spirometry in JIA patients demonstrated statistically significant restrictive pattern of alteration in pulmonary function.

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Acknowledgments

The authors express heart-felt gratitude to the postgraduate trainees of department of pediatrics, I.P.G.M.E.&R., Kolkata for their unconditioned help.

Contributions

MMA, SS were involved in conception and design of the study. MMA, SS searched the literature. RM, SS, NKD were involved in patient management. MMA, BR, OM were involved in data collection. MMA, AH were involved in analysis and interpretation of data. MMA, OM drafted the manuscript. RM, SS critically reviewed the manuscript. All the authors finally approved the manuscript. MMA will act as the guarantor.

Conflict of Interest

None.

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Authors and Affiliations

  1. Department of Physiology, Institute of Postgraduate Medical Education & Research, Kolkata, India

    Md. Mahboob Alam

  2. Department of Physiology, Malda Medical College, Malda, West Bengal, India

    Biman Ray

  3. Department of Pediatrics, Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India

    Sumantra Sarkar & Niloy Kumar Das

  4. Department of Physiology, Medical College, Kolkata, West Bengal, India

    Oona Mandal

  5. Department of Pediatrics, North Bengal Medical College and Hospital, Darjeeling, West Bengal, India

    Rakesh Mondal

  6. Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India

    Avijit Hazra

  7. 54, Alimuddin Street, Kolkata, 700016, West Bengal, India

    Md. Mahboob Alam

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  1. Md. Mahboob Alam
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  2. Biman Ray
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  3. Sumantra Sarkar
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Correspondence to Md. Mahboob Alam.

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Alam, M.M., Ray, B., Sarkar, S. et al. Spirometric Evaluation in Juvenile Idiopathic Arthritis: Data from Eastern India. Indian J Pediatr 81, 1010–1014 (2014). https://doi.org/10.1007/s12098-013-1335-x

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  • DOI: https://doi.org/10.1007/s12098-013-1335-x

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