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Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India

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Abstract

Objectives

To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children.

Methods

This was a prospective case–control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1–15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL.

Results

Fifty asthmatics and 25 age-matched controls were recruited from August 2011–July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25–42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ 2 for trend = 24.96 (p = 0.000)].

Conclusions

25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.

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Acknowledgments

Authors are thankful to Dr. Abbas Ali Mahdi, Head of the Department of Biochemistry for estimation of serum level of vitamin D in his laboratory.

Contributions

SA: Conceptualized the study and supervised the data collection and analysis; KV: Data collection, data entry and analysis. SA and KV both were responsible for manuscript write up. SA will act as guarantor for this manuscript.

Conflict of Interest

None.

Role of Funding Source

This study was funded by Prarthana Clinic, Lucknow and Kumar Diagnostic Centre, Faizabad.

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Authors and Affiliations

  1. Department of Pediatrics and Translational Medicine Unit, King George’s Medical University, Lucknow, 226003, India

    Shally Awasthi & Kumar Vikram

Authors
  1. Shally Awasthi
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  2. Kumar Vikram
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Correspondence to Shally Awasthi.

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Awasthi, S., Vikram, K. Serum 25 Hydroxy Vitamin D Insufficiency Associated with Bronchial Asthma in Lucknow, India. Indian J Pediatr 81, 644–649 (2014). https://doi.org/10.1007/s12098-013-1310-6

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  • DOI: https://doi.org/10.1007/s12098-013-1310-6

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